2017年

原著論文

Seira N*, Yanagisawa N*, Suganami A, Honda T, Wasai M, John W. R, Fukushima K, Yamaguchi N, Tamura Y, Arai T, Fujino H, Murayama T.: Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. (2017) Biol. Pharm. Bull. 40:1806-1812. (* Equally contributed two top authors)

Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, Yoshino I, Tatsumi K, Murayama T.: Antifibrotic effects of cyclosporine A on TGF-β1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α. (2017) FASEB J. 31(8):3359-3371.

Nakamura H, Moriyama Y, Watanabe K, Tomizawa S, Yamazaki R, Takahashi H, Murayama T.: Lactosylceramide-Induced Phosphorylation Signaling to Group IVA Phospholipase A2 via Reactive Oxygen Species in Tumor Necrosis Factor-α-Treated Cells. (2017) J Cell Biochem. 118(12):4370-4382.

2016年

原著論文

Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T.: Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. (2016) FEBS journal. 283, 3931-3940.

Hashimoto N, Matsumoto I, Takahashi H, Ashikawa H, Nakamura H, Murayama T.: Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme. (2016) Neuropharmacology. 110, 458-69.

Matsuzaki W, Takahashi H, Nakamura H, Murayama T.: Effects of glycerophospholipids on ceramide kinase activity: cardiolipin-affected cellular formation of ceramide-1-phosphate. (2016) Biol. Pharm. Bull. 39, 1708-1717.

2015年

原著論文

Yui K, Imataka G, Nakamura H, Ohara N, Naito Y.: Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders. (2015) Curr Neuropharmacol. 13, 776-785

Fujino H.: The roles of EP4 prostanoid receptors on cancer malignancy signaling. (2015) Biol. Pharm. Bull. Review. 39, 149-55

Fujino H, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, Murayama T.: Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. (2015) Eur. J. Pharmacol. 768, 149-59

Yamane S, Nomura R, Yanagihara M, Nakamura H, Fujino H, Matsumoto K, Horie S, Murayama T.: L-cysteine/d,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments. (2015) Eur. J. Pharmacol. 764, 471-479

Nakamura H, Wakita S, Yasufuku K, Makiyama T, Waraya M, Hashimoto N, Murayama T.: Sphingomyelin regulates the activity of secretory phospholipase A2 in the plasma membrane. (2015) J. Cell. Biochem. 116, 1898-1907

Tanimoto J, Fujino H, Takahashi H, Murayama T.: Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors. (2015) FEBS letters. 589, 766-772

Makiyama T, Nakamura H, Nagasaka N, Yamashita H, Honda T, Yamaguchi N, Nishida A and Murayama T.: Trafficking of acetyl-C16-ceramide-NBD with long-term stability and no cytotoxicity into the Golgi. (2015) Traffic. 16, 476-492

Otake S, Yoshida K, Seira N, Sanchez CM, Regan JW, Fujino H & Murayama T.: Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells. (2015) Pharma. Res. Per. 3, e00083

2014年

原著論文

Yamane S, Kanno T, Nakamura H, Fujino H, Murayama T.: Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels. (2014) Eur. J. Pharmacol. 740, 112-120

Matsumoto K, Hosoya T, Ishikawa E, Tashima K, Amagase K, Kato S, Murayama T, Horie S.: Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus. (2014) Hostichem. Cell Biol. 142, 635-644

Hosoya T, Matsumoto K, Tashima K, Nakamura H, Fujino H, Murayama T, Horie S.:TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. (2014) Neurogastroenterol. Motil. 26, 1112-1121

Oyama S, Fujino H, Yamazaki R, Okura I, Regan JW, Awata A, Arai T, Murayama T.: A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. (2014) Arch. Biochem. Biophys. 541, 21-29.

Akiyama N, Akiyama Y, Kato H, Kuroda T, Ono T, Imagawa K, Asakura K, Shinosaki T, Murayama T, Hanasaki K.: Pharmacological evaluation of adipose of dyfunction via 11βhydroxysteroid dehydrogenase type 1 in the development of diabetes-induced obesity mice with cortisone pellet implantation. (2014) J. Pharmacol. Exp. Ther. 349, 66-74

Sasaki H, Toyomura K, Mastuzaki W, Okamoto A, Yamaguchi N, Nakamura H, Murayama T.: Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. (2014) Arch. Biochem. Biophys. 550-551, 12-19

2013年

原著論文

Nakamura H.: Modulation of arachidonic acid metabolism in niemann-pick disease type C cells. (2013) Curr. Psychopharmacol. 2, 58-65.

Nakamura H, Moriyama Y, Makiyama T, Emori S, Yamashita H, Yamazaki R, Murayama T.: Lactosylceramide interacts with and activates cytosolic phospholipase A2α.(2013) J. Biol. Chem. 288, 23264-23272

Yoshida K, Fujino H, Otake S, Seira N, Regan JW, Murayama T.: Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. (2013) Eur. J. Pharmacol. 718,408-17

Nomura R*, Yanagihara M*, Sato H, Matsumoto K, Tashima K, Horie S, Chen S, Fujino H, Ueno K, Murayama T.: Bee venom phospholipase A2-induced phasic contractions in mouse rectum: independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis. (2013) Eur. J. Pharmacol. 718,314-22(* Equally contributed two top authors)

2012年

原著論文

Makiyama T, Nakamura H, Nishida A, Murayama T.: C2-Di-ethyl-ceramide-1-phosphate as an inhibitor of group IVA cytosolic phospholipase A2. (2012) Eur. J. Pharmacol. 697, 144-151.

Kawashima T*, Yamazaki R*, Matsuzawa Y, Yamaura E, Takabatake M, Otake S, Ikawa Y, Nakamura H, Fujino H, Murayama T.: Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-sutimulated lung fibroblasts. (2012) Eur. J. Pharmacol. 696, 120-129. (* Equally contributed two top authors)

Toyomura K, Saito T, Emori S, Matsumoto I, Kato E, Kaneko S, Okuma Y, Nakamura H, Murayama T.: Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells. (2012) J. Toxicol. Sci. 37, 1049-1057.

Ikawa Y, Fujino H, Otake S, Murayama T.: Indomethacin antagonizes EP2 prostanoid receptor activation in LS174T human colon cancer cells. (2012) Eur. J. Pharmacol. 680, 16-21.

Matsumoto K, Lo MW, Hosoya T, Tashima K, Takayama H, Murayama T, Horie S.: Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. (2012) Lab. Invest. 92, 769-782.

Nakamura H, Yasufuku K, Makiyama T, Matsumoto I, Fujino H, Murayama T.: Arachidonic acid metabolism via cytotoloc phospholipase A2α induces cytotoxicity in Niemann-Pick disease type C cells. (2012) J. Cell. Physiol. 227, 2847-2855.

Kato E, Yamane S, Nomura R, Matsumoto K, Tashima K, Horie S, Saito T, Fujino H, Murayama T.: Dysfunction of neurogenic VIP-induced relaxation in mouse distal colon with dextran sulfate sodium-induced colitis. (2012) Pharmacol. Res. 65,204-212.

Hamada Y, Kato E, Nakamura H, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T.: Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment. (2012) Naunyn-Schmiedebergs Arch. Pharmacol. 385, 81-94.

2011年

原著論文

Matsumoto K, Hosoya T, Tashima K, Namiki T, Murayama T, Horie S.: Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons. (2011) Neuroscience 172, 518-534.

Fujino H, Toyomura K, Chen X, Regan JW, Murayama T.: Prostaglandin E(2) regulates cellular migration via induction of vascular endothelial growth facter receptor-1 in HCA-7 human colon cancer cells. (2011) Biochem. Pharmacol. 81, 379-387.

Nakamura H, Tada E, Makiyama T, Yasufuku K, Murayama T.: Role of cytosolic phospholipase A2α in cell rounding and cytotoxicity induced by ceramide-1-phosphate via ceramide kinase. (2011) Arch. Biochem. Biophys. 512, 45-51.

Kato T, Fujino H, Oyama S, Kawashima T, Murayama T.: Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect. (2011) Biochem. Pharmacol. 82, 1781-1791.

Kawada K, Kaneko M, Nomura Y, Mimori S, Hamana H, Ogita K, Murayama T, Fujino H, Okuma Y.: Expression of the ubiquitin ligase HRD1 in neural stem/progenitor cells of the adult mouse brain. (2011) J. Pharmacol. Sci. 117, 208-212

Matsuzawa Y, Kawashima T, Yamazaki R, Yamaura E, Makiyama T, Fujino H, Murayama T.: Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-β1-induced expression of α-smooth muscle actin in human fetal lung fibroblasts. (2011) J. Toxicol. Sci. 36, 733-740

2010年

原著論文

Hamada Y, Murakami I, Katoh E, Yamane S, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T.:Neurogenic contraction of mouse rectum via the cyclooxygenase pathway; changes of PGE2-induced contraction with dextran sulfate sodium-induced colitis. (2010) Pharmacol.Res. 61, 48-57

Orido T, Fujino H, Kawashima T, Murayama T.:Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells: a novel cyclooxygenase-2-inhibition-independent effect. (2010) Arch. Biochem. Biophys. 494, 78-85

Nakamura H, Wakita S, Suganami A, Tamura Y, Hanada K, Murayama T.: Modulation of the activity of cytosolic phospholipase A2α (cPLA2α) by cellular sphingolipids and inhibition of cPLA2α by sphingomyelin. (2010) J. Lipid Res. 51, 720-728

Makiyama T, Nagasaka N, Houjyo Y, Yamaura E, Nakamura H, Koide Y, Nishida A, Murayama T.:Newly synthetic ceramide-1-phosphate analogs: their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A2α and inducer of cell toxicity. (2010) Biochem. Pharmacol. 80, 1396-1406.

Fujino H, Murayama T, Regan JW.:Assessment of constitutive activity in E-type prostanoid receptors. (2010) Methods Enzymol. 484:95-107

Mashimo M, Okubo Y, Yamazawa T, Yamasaki M, Watanabe M, Murayama T, Iino M.: Inositol 1,4,5-triphosphate signaling maintains the activity of glutamate uptake in Bergmann glia. (2010) Eur. J. Neurosci. 32, 1668-1677.

Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T.:Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway. (2010) J. Pharmacol. Sci. 114, 420-432.

藤野裕道.: インドメタシンの新たな抗癌機構の解明 : シクロオキシゲナーゼ阻害非依存的作用の探究 (2010) 千葉医学. 86, 251.

2009年

原著論文

Shimizu M, Muramatsu Y, Tada E, Kurosawa T, Yamaura E, Nakamura H, Fujino H, Houjyo Y, Miyasaka Y, Koide Y, Nishida A, Murayama T.:Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2α-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells : the structure-activity relationship. (2009) J. Pharmacol. Sci. 111, 182-192.

Kurosawa T, Nakamura H, Yamaura E, Fujino H, Matsuzawa Y, Kawashima T, Murayama T.:Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A2α-dependent and -independent release of arachidonic acid.(2009) J. Cell. Physiol. 219, 606-616.

Matsumoto K, Kurosawa E, Terui H, Hosoya T, Tashima K, Murayama T, Priestley JV, Horie S.:Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine; high abundance and sensitivity in rectum and distal colon. (2009) Am. J. Physiol. Gastrointest. Liver Physiol. 297,G348-G360.

Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, Murayama T, Kawashima T.:Activation of cytosolic phospholipase A2a by epidermal growth factor (EGF) and phorbol ester in Hela cells; different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf. (2009) J. Pharmacol. Sci. 111, 182-192.

Shimizu M, Tada E, Makiyama T, Yasufuku K, Fujino H, Nakamura H, Murayama T.: Effects of ceramide, ceramidase inhibition and expression of ceramide kinase on cytesolic phospholipase A2α; additional role of ceramide-1-phosphate in phosphorylation and Ca2+ signaling.(2009) Cell. Signal. 21, 440-447

Murakami I, Hamada Y, Yamane S, Fujino H, Horie S, Murayama T.: Nicotine-induced neurogenic relaxation in the mouse colon ; changes with dextran sodium sulfate-induced colitis.(2009) J. Pharmacol. Sci. 109, 128-138.

2008年

原著論文

Taniguchi T, Fujino H, Israel DD, Regan JW, Murayama T.:Human EP3(I) prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression.(2008) Biochem. Biophys. Res. Commun. 377:1173-1178

Orido T, Fujino H, Hasegawa Y, Toyomura K, Kawashima T, Murayama T.: Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.(2008) J. Pharmacol. Sci. 108,389-392

Matsumoto K, Takayama H, Narita M, Nakamura A, Suzuki M, Suzuki T, Murayama T, Wongseripipatana S, Misawa K, Kitajima M, Tashima K, Horie S.:MGM-9[(E)-methyl 2-(3-ethyl-7a,12a-(epxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine : A novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice.(2008) Neuropharmacol. 55, 154-165

Mashimo M, Hirabayashi T, Murayama T, Shimizu T.:Cytosolic PLA2α activation in Purkinje neurons and its role in AMPA-receptor trafficking.(2008) J. Cell. Sci. 121, 3015-3024

Nabemoto M, Mashimo M, Someya A, Nakamura H, Hirabayashi T, Fujino H, Kaneko M, Okuma Y, Saito T, Yamaguchi N, Murayama T.: Release of arachidonic acid by 2-arachidonoyl glycerol and HU 210 in PC12 cells ; roles of Src, phospholipase C and cytosolic phospholipase A2α.(2008) Eur. J. Parmacol. 590,1-11

Xu W, Chou CL, Sun H, Fujino H, Chen QM, Regan JW.: FP prostanoid receptor-mediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogen-activated protein kinase signaling cascade.(2008) Mol. Pharmacol. 73, 111-118

Shimizu M, Matsumoto Y, Kurosawa T, Azuma C, Enomoto M, Nakamura H, Hirabayashi T, Kaneko M, Okuma Y, Murayama T.: Release of arachidonic acid induced by tumor necrosis factor-α in the presence of caspase inhibition: Evidence for a cytosolic phospholipase A2α-independent pathway.(2008) Biochem. Pharm. 75, 1358-1369

Shimizu M, Nakamura H, Hirabayashi T, Suganami A, Tamura Y, Murayama T.: Ser515 phosphorylation-independent regulation of cytosolic phospholipaseA2α (cPLA2α) by calmodulin-dependent protein kinase: Possible interaction with catalytic domain A of cPLA2α.(2008) Cell. Signal. 20, 815-824

総説

H. Fujino, J.W. Regan. Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer? Trends Pharmacol. Sci. 24:335-340, 2003.

Fujino H, Murayama T, Regan JW.: Assessment of constitutive activity in E-type Prostanoid receptors. (2010) Methods Enzymol. 484, 95-107.

藤野裕道, 村山俊彦.: インドメタシンの新たな抗がん機構の解明 : シクロオキシゲナーゼ阻害非依存的作用の探究 日薬理誌 (Folia Parmacol. Jpn). 137:177-181, 2011.

Nakamura H, Murayama T.: The role of sphingolipids in arachidonic acid metabolism. (2014) J. Pharmacol. Sci. 124, 307-312.

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