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@Selected publications 2004-2013.

Full publication list by Researcher ID:
Professor
Dr. Kazuki Saito



Associate Professor
Dr. Mami Yamazaki


Assistant Professor
Dr. Naoko Yoshimoto


  1. Mami Yamazaki, Keiichi Mochida, Takashi Asano, Ryo Nakabayashi, Motoaki Chiba, Udomson Nirin, Yasuyo Yamazaki, Dayan B. Goodenowe, Ushio Sankawa, Takuhiro Yoshida, Atsushi Toyoda, Yasushi Totoki, Yoshiyuki Sakaki, Elsa Gogora-Castill, C. Robin Buell, Tetsuya Sakurai and Kazuki Saito:
    Coupling deep transcriptome analysis with untargeted metabolic profiling in Ophiorrhiza pumila to further the understanding of the biosynthesis of the anti-cancer alkaloid camptothecin and anthraquinones.
    Plant Cell Physiol., 54, 686-696 (2013)
  2. Somnuk Bunsupa, Kae Katayama, Emi Ikeura, Akira Oikawa, Kiminori Toyooka, Kazuki Saito, and Mami Yamazaki:
    Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in Leguminosae.
    Plant Cell., 24, 1202-1216 (2012)
  3. Keiko Yonekura-Sakakibara, Atsushi Fukushima, Ryo Nakabayashi, Kousuke Hanada, Fumio Matsuda, Satoko Sugawara, Eri Inoue, Takashi Kuromori, Takuya Ito, Kazuo Shinozaki, Bunyapa Wangwattana, Mami Yamazaki and Kazuki Saito:
    Two glycosyltransferases involved in anthocyanin modification delineated by transcriptome independent component analysis in Arabidopsis thaliana.
    Plant J., 69, 154-167 (2012)
  4. Hikaru Seki, Satoru Sawai, Kiyoshi Ohyama, Masaharu Mizutani, Toshiyuki Ohnishi, Hiroshi Sudo, Ery Odette Fukushima, Tomoyoshi Akashi, Toshio Aoki, Kazuki Saito and Toshiya Muranaka:
    Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin.
    Plant Cell., 23, 4112-4123 (2011)
  5. Kazuki Saito and Fumio Matsuda:
    Metabolomics for functional genomics, systems biology, and biotechnology.
    Annu. Rev. Plant Biol., 61, 463-489 (2010)
  6. Mami Yamazaki, Takashi Asano, Yasuyo Yamazaki, Supaart Sirikantaramas, Hiroshi Sudo and Kazuki Saito:
    Biosynthetic system of camptothecin: an anticancer plant product.
    Pure Appl.Chem., 82, 213-218 (2010)
  7. Sarah G. Mugford, Naoko Yoshimoto, Michael Reichelt, Markus Wirtz, Lionel Hill, Sam T. Mugford, Yoshimi Nakazato, Masaaki Noji, Hideki Takahashi, Robert Kramell, Tamara Gigolashvili, Ulf-Ingo Fluege, Claus Wasternack, Jonathan Gershenzon, Ruediger Hell, Kazuki Saito, and Stanislav Kopriva:
    Disruption of adenosine-5-phosphosulphate kinase in Arabidopsis reduces levels of sulphated secondary metabolites.
    Plant Cell, 21, 910-927 (2009)
  8. Ryo Nakabayashi, Miyako Kusano, Makoto Kobayashi, Takayuki Tohge, Keiko Yonekura-Sakakibara, Noriyuki Kogure, Mami Yamazaki, Mariko Kitajima, Kazuki Saito and Hiromitsu Takayama:
    Metabolomics-oriented isolation and structure elucidation of 37 compounds including two new anthocyanins from Arabidopsis thaliana. Phytochemistry, 70, 1017-1029 (2009)
  9. Mutsumi Watanabe, Keiichi Mochida, Tomohiko Kato, Satoshi Tabata, Naoko Yoshimoto, Masaaki Noji, and Kazuki Saito:
    Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis. Plant Cell, 20,2484-2496 (2008)
  10. Hikaru Seki, Kiyoshi Ohyama, Satoru Sawai, Masaharu Mizutani, Toshiyuki Ohnishi, Hiroshi Sudo, Tomoyoshi Akashi, Toshio Aoki, Kazuki Saito and Toshiya Muranaka:
    Licorice b-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proc. Natl. Acad. Sci. USA, 105, 1420414209 (2008)
  11. Mami Yamazaki, Masahisa Shibata, Yasutaka Nishiyama, Karin Springob, Masahiko Kitayama, Norimoto Shimada, Toshio Aoki, Shin-ichi Ayabe, and Kazuki Saito:
    Differential gene expression profiles of red and green forms of Perilla frutescens leading to comprehensive identification of anthocyanin biosynthetic genes. FEBS J., 275, 3494-3502 (2008)
  12. Supaart Sirikantaramas, Mami Yamazaki, and Kazuki Saito:
    Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants. Proc. Natl. Acad. Sci. USA, 105, 6782-6786 (2008)
  13. Mutsumi Watanabe, Miyako Kusano, Akira Oikawa, Atsushi Fukushima, Masaaki Noji and Kazuki Saito:
    Physiological roles of -substituted alanine synthase gene (Bsas) family in Arabidopsis thaliana. Plant Physiol., 146, 310-320 (2008)
  14. Naoko Yoshimoto, Eri Inoue, Akiko Watanabe-Takahashi, Kazuki Saito, Hideki Takahashi:
    Post-transcriptional regulation of high-affinity sulfate transporters in Arabidopsis by sulfur nutrition. Plant Physiol., 145, 378-388 (2007)
  15. Supaart Sirikantaramas, Hiroshi Sudo, Takashi Asano, Mami Yamazaki, Kazuki Saito:
    Transport of camptothecin in hairy roots of Ophiorrhiza pumila. Phytochemistry, 68, 2881-2886 (2007)
  16. Jie Luo, Yasutaka Nishiyama, Christine Fuell, Goro Taguchi, Katherine Elliott, Lionel Hill, Yoshikazu Tanaka, Masahiko Kitayama, Mami Yamazaki, Paul Bailey, Adrian Parr, Anthony J. Michael, Kazuki Saito and Cathie Martin:
    Convergent evolution in the BAHD family of acyl transferases; identification and characterization of anthocyanin acyl transferases from Arabidopsis thaliana. Plant J., 50, 678-695 (2007)
  17. Takeshi Obayashi, Kengo Kinoshita, Kenta Nakai, Masayuki Shibaoka, Shinpei Hayashi, Motoshi Saeki, Daisuke Shibata, Kazuki Saito, and Hiroyuki Ohta:
    ATTED-II: a database of co-expressed genes and cis elements for identifying co-regulated gene groups in Arabidopsis. Nucleic Acids Res., 35, D863-869 (2007)
  18. Kazuki Saito and Mami Yamazaki eds:
    Current Pharmaceutical Biotechnology. Special issue eMedicinal Plant Biotechnologyf. Volume 8, Number 4, August 2007. Bentham Science Publishers, Oak Park, IL.
  19. Yasuhiro Higashi, Masami Yokota Hirai, Toru Fujiwara, Satoshi Naito, Masaaki Noji, and Kazuki Saito:
    Proteomics and transcriptomic analysis of Arabidopsis seeds: Molecular evidence for successive processing of seed proteins and its implication in stress response to sulfur nutrition. Plant J., 48, 557-571 (2006)
  20. Jun-ichiro Nakajima, Yoshiharu Sato, Tyuji Hoshino, Mami Yamazaki, and Kazuki Saito:
    Mechanistic study on the oxidation of anthocyanidin synthase by quantum mechanical calculation. J. Biol. Chem., 281, 21387-21398 (2006)
  21. Kazuki Saito, Richard A. Dixon, Lothar Willmitzer eds:
    Biotechnology in Agriculture and Forestry 57 Plant Metabolomics, Springer Verlag, Heidelberg, (2006)
  22. Masami Yokota Hirai, Marion Klein, Yuuta Fujikawa, Mitsuru Yano, Dayan B. Goodenowe, Yasuyo Yamazaki, Shigehiko Kanaya, Yukiko Nakamura, Masahiko Kitayama, Hideyuki Suzuki, Nozomu Sakurai, Daisuke Shibata, Jim Tokuhisa, Michael Reichelt, Jonathan Gershenzon, Jutta Papenbrock, and Kazuki Saito:
    Elucidation of gene-to-gene and metabolite-to-gene networks in Arabidopsis by integration of metabolomics and transcriptomics. J. Biol. Chem., 280, 25590-25595 (2005)
  23. Takayuki Tohge, Yasutaka Nishiyama, Masami Yokota Hirai, Mitsuru Yano, Jun-ichiro Nakajima, Motoko Awazuhara, Eri Inoue, Hideki Takahashi, Dayan B. Goodenowe, Masahiko Kitayama, Masaaki Noji, Mami Yamazaki and Kazuki Saito:
    Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants overexpressing a MYB transcription factor. Plant J., 42, 218-235 (2005)
  24. Taketo Okada, Masami Yokota Hirai, Hideyuki Suzuki, Mami Yamazaki and Kazuki Saito:
    Molecular characterization of a novel quinolizidine alkaloid O-tigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants. Plant Cell Physiol., 46, 233-244 (2005)
  25. Cintia Goulart Kawashima, Oliver Berkowitz, Ruediger Hell, Masaaki Noji and Kazuki Saito:
    Characterization and expression analysis of a serine acetyltransferase gene family involved in a key step of the sulphur assimilation pathway in Arabidopsis thaliana. Plant Physiol., 137, 220-230 (2005)
  26. Takashi Asano, Ikumi Watase, Hiroshi Sudo, Mariko Kitajima, Hiromitsu Takayama, Norio Aimi, Mami Yamazaki and Kazuki Saito:
    Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O. kuroiwai. Plant Biotech., 21, 275-281 (2004)
  27. Masami Yokota Hirai, Mitsuru Yano, Dayan B. Goodenowe, Shigehiko Kanaya, Tomoko Kimura, Motoko Awazuhara, Masanori Arita, Toru Fujiwara and Kazuki Saito:
    Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA, 101, 10205-10210 (2004)
  28. Yasuyo Yamazaki, Mariko Kitajima, Masanori Arita, Hiromitsu Takayama, Hiroshi Sudo, Mami Yamazaki, Norio Aimi and Kazuki Saito:
    Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C] glucose. Plant Physiol., 134, 161-170 (2004)
  29. Jonathan J. Turnbull, Jun-ichiro Nakajima, Richard W.D. Welford, Mami Yamazaki, Kazuki Saito and Christopher J. Schofield:
    Mechanistic studies on three 2-oxoglutarate dependent oxygenases of flavonoid biosynthesis: Anthocyanidin synthase, flavonol synthase and flavanone 3beta-hydroxylase. J. Biol. Chem., 279, 1206-1216 (2004)
  30. Raoul J. Bino, Robert D. Hall, Oliver Fiehn, Joachim Kopka, Kazuki Saito, John Draper, Basil J. Nikolau, Pedro Mendes, Ute Roessner-Tunali, Michael H. Beale, Richard N. Trethewey, B. Markus Lange, Eve Syrkin Wurtele and Lloyd W. Sumner:
    Potential of metabolomics as a functional genomics tool. Trends Plant Sci., 9, 418-425 (2004)
  31. Kazuki Saito:
    Sulfur Assimilatory Metabolism. The Long and Smelling Road. Plant Physiol., 136, 2443-2450 (2004)