Original Articles
1. Manome, T.; Hara, Y.; Ishibashi, M. "Isolation of various flavonoids with TRAIL-resistance
overcoming activity from Blumea lacera" Molecules 2023, 28, 264 DOI:10.3390/molecules28010264
2. Manome, T.; Hara, Y.; Ishibashi, M. "A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance
overcoming activity of physalins" J.
Nat. Med. in press DOI:10.1007/s11418-022-01670-x Shareable
Link:
https://rdcu.be/c1nI4
3. Fujii, K.; Hara, Y.; Arai, M. A.; Sadhu, S.
K.; Ahmed, F.; Ishibashi, M. "Natural compounds with BMI1 promoter
inhibitory activity from Mammea siamensis
and Andrographis paniculata" Chem. Pharm. Bull. 2022,
70, 885-891 DOI:10.1248/cpb.c22-00556
4. Jitrangsri, K.; Hara, Y.; Takaya, A.;
Ishibashi, M. "New polyoxygenated cyclohexenes isolated from Uvaria rufa and cinnamtannin B1 isolated
from Nephelium hypoleucum with
TRAIL-resistance-overcoming activity" Phytochem.
Lett.
2022, 52, 7-9 DOI:10.1016/j.phytol.2022.08.010
5. Hara, Y.; Watanabe, K.; Takaya, A.; Ebihara, I.; Manome, T.; Arai,
M. A.; Yaguchi, T.; Ishibashi, M. "Two bioactive compounds, uniformides A
and B, isolated from a culture of
Nocardia uniformis IFM0856T in the presence of animal
cells" Org. Lett. 2022, 24, 5867 and 4998-5002 DOI:10.1021/acs.acs.orglett.2c02441; DOI:10.1021/acs.acs.orglett.2c02092
6. Jitrangsri, K.; Kamata, K.; Akiba, M.;
Yajiri, Y.; Ishibashi, M.; Tatsuzaki, J.; Ishikawa, T. "Is
18α-glycyrrhizin a real natural product? Improved preparation of
18α-glycyrrhizin from 18β-glycyrrhizin as a positive standard for HPLC analysis
of licorice extracts" J. Nat. Med. 2022, 76, 367-378 DOI:10.1007/s11418-021-01589-9 Shareable
Link:
https://rdcu.be/cFM1U
7. Manome, T.; Hara, Y.; Ahmed, F.; Sadhu, S.
K.; Ishibashi, M. "Thannilignan glucoside
and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds
isolated from Terminalia bellirica" J. Nat. Med. 2022, 76, 482-489 DOI:10.1007/s11418-021-01593-z Shareable Link: https://rdcu.be/cFbQ1
8.
Makita,
Y.; Saito, S.; Tsuchiya, A.; Ishibashi, M.; Arai, M. A. "Identification of 1β,2α-epoxytagitinin
C as a Notch inhibitor and evaluation of its anti-leukemia activity" J. Nat. Med. 2022, 76, 234-243 DOI:10.1007/s11418-021-01584-0
Shareable Link: https://rdcu.be/cBZAh
9.
Hara, Y.; Chiba, M.; Watanabe, K.; Ishibashi, M. "Isolation of ikahonone,
4-methyl-2,4-dihydroxy-3-pentanone from Bacillus
cereus IFM12235"
Heterocycles 2022, 105, 523-531 DOI:10.3987/COM-21-S(R)4
10.
Hara, Y.; Tanimura, D.; Manome, T.; Arai, M. A.; Yaguchi, T.;
Ishibashi, M. "Isolation of peptidolipin NA derivatives from the culture
of Nocardia arthritidis IFM10035T
in the presence of mouse macrophage cells" Heterocycles 2022, 104, 185-190
DOI:10.3987/COM-21-14567
11. Jitrangsri, K.; Takaya, A.; Hara, Y.; Sadhu,
S. K.; Ahmed, F.; Ishibashi, M. "Bioactivity-guided isolation of
TRAIL-resistance overcoming activity compounds from the leaves of Murraya exotica" Nat. Prod. Commun. 2021, 16 (12), 1934578X211065843 DOI:10.1177/1934578X211065843
12.
Arai, M. A.; Sakuraba, K.; Makita, Y.; Hara, Y.; Ishibashi, M.
"Evaluation of naturally occurring HIF-1 inhibitors for
pulmonary arterial hypertension" ChemBioChem 2021, 22, 2799-2804 DOI:10.1002/cbic.202100223
13.
Kondo, M.; Matsuyama, N.; Aye, T. Z.;
Mattan, I.; Sato, T.; Makita, Y.; Ishibashi, M.; Arai, M. A.; Takizawa, S.;
Sasai, H. "Practical stereoselective synthesis of
C3-spirooxindole- and C2-spiropseudoindoxyl-pyrrolidines via organocatalyzed
Pictet-Spengler reaction/oxidative rearrangement sequence" Adv. Synth. Catal. 2021, 363, 2648-2663 DOI:10.1002/adsc.202001472
14.
Ohizumi, Y.; Kawada, M.; Kamada, M.; Nakajima, A.; Kajima, K.;
Uozumi, N.; Hara, Y.; Guo, Y.; Ishibashi, M. "Isolation
of adenosine and cordysinin B from Anredera
cordifolia that stimulates CRE-mediated transcription in PC12 cells" Planta Med. Int. Open 2021, 8, e19-e24 DOI:10.1055/a-1395-6510
15.
Arai, M. A.; Ebihara, I.; Makita, Y.; Hara, Y.; Yaguchi, T.;
Ishibashi, M. "Isolation of nocobactin NAs as
Notch signal inhibitors from Nocardia farcinica, a possibility of
invasive evolution"
J. Antibiot. 2021, 74, 255-259
DOI:10.1038/s41429-020-00393-z
Shareable Link: https://rdcu.be/cb9Zd
16.
Hara, Y.; Totsugi, Y.; Ichikawa, H.; Harada, S.; Fujii, K.; Ahmed,
F.; Sadhu, S. K.; Arai, M. A.; Ishibashi, M. "Acacienone, a terpenoid-like natural product
having an unprecedented C20 framework isolated from Acacia mangium leaves" J. Nat. Med. 2021, 75, 99-104 DOI:10.1007/s11418-020-01457-y
Shareable Link: https://rdcu.be/b8t6L
17.
Nakamura,
Y.; Takahashi, H.; Takaya, A.; Inoue, Y.; Katayama, Y.; Kusuya, Y.; Shoji, T.;
Takada, S.; Nakagawa, S.; Oguma, R.; Saito, N.; Ozawa, N.; Nakano, T.; Yamaide,
F.; Dissanayake, E.; Suzuki, S.; Villaruz, A.; Varadarajan, S.; Matsumoto, M.;
Kobayashi, T.; Kono, M.; Sato, Y.; Akiyama, M.; Otto, M.; Matsue, H.; Nunez,
G.; Shimojo, N. "Staphylococcus
Agr virulence is critical for epidermal colonization and associates with atopic
dermatitis development" Sci Transl Med. 2020,
12, eaay4068
18.
Sun,
X.; Kawata, K.; Miki, A.; Wada, Y.; Nagahama, M.; Takaya, A.; Akimitsu, N. "Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation" Biosci
Trends. 2020, 14, 255-262
19.
Arai, M. A.; Makita, Y.; Yamaguchi, Y.; Kawano, H.; Suganami, A.;
Tamura, Y.; Ishibashi, M. "Total synthesis of
lindbladione, a Hes1 dimerization inhibitor and neural stem
cell activator isolated from Lindbladia
tubulina"
Sci. Rep. 2020, 10, 21433 DOI:10.1038/s41598-020-78524-7
20.
Tsuchiya, A.; Makita, Y.; Koyano, T.; Kowithayakorn, T.; Ishibashi,
M.; Arai, M. A. "Isolation and evaluation of
cardenolides from Lansium domesticum
as Notch inhibitors"
J. Nat. Med. 2020, 74, 758-766 DOI:10.1007/s11418-020-01432-7
Shareable Link: https://rdcu.be/b5x4r
21.
Arai, M. A.; Morita, K.; Kawano, H.; Makita, Y.; Hashimoto, M.;
Suganami, A.; Tamura, T.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Target protein-oriented isolation of Hes1 dimer inhibitors using
protein based methods" Sci. Rep. 2020, 10, 1381 DOI:10.1038/s41598-020-58451-3
22.
Sato, T.; Arai, M. A.; Yixizhuoma; Hara, Y.; Koyano, T.;
Kowithayakorn, T.; Ishibashi, M. "Cadinane sesquiterpenoids isolated from Santalum album using a screening program
for Wnt signal inhibitory activity" J. Nat. Med. 2020, 74, 476-481 DOI:10.1007/s11418-019-01380-x
Shareable Link: https://rdcu.be/b2eo8
23.
Sakai, K.; Hara, Y.; Ishibashi, M.; Sakai, M.; Kawahara, S.;
Imanishi, S.; Harada, K.; Hoshino, Y.; Komaki, H.; Mukai, A.; Gonoi, T.
"Characterization of nocardithiocin derivatives produced by amino acid
substitution of precursor peptide notG" Int. J. Pept. Res. Ther. 2020,
26, 281-290 DOI:10.1007/s10989-019-09836-0
24.
Kobayashi, N.; Hara, Y.; Arai, M. A.; Hara, S.; Gonoi, T.; Yaguchi,
T.; Ishibashi, M. "Isolation of inohanalactone, a γ-butyrolactone,
from Nocardia inohanensis IFM0092T" Heterocycles 2020, 101, 312-317 DOI:10.3987/COM-19-S(F)11
25.
Yokoyama, Y.; Arai, M. A.; Hara, Y.; Ishibashi, M. "Nonactic acid derivatives isolated from Streptomyces werraensis IFM12104 in a screening program for BMI1 promoter inhibitory
activity"
Nat. Prod. Commun. 2019, 14 (7) 1-5, DOI:10.1177/1934578X19866583
26.
Endo, Y.; Kasahara, T.; Asakura, K.; Funasaki, M.; Akisue, G.; Etoh,
T.; Matsuzaki, K.; Ishibashi, M.; Ohsaki, A. "Sucupiranins
M–Q, five new furanocassane-type diterpenoids from the seeds of Bowdichia virgilioides" Tetrahedron 2019, 75, 130511 DOI:10.1016/j.tet.2019.130511
27.
Yokoyama, Y.; Arai, M. A.; Hara, Y.; Ishibashi, M.
"Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958" Bioorg. Med. Chem. 2019,
27, 2998-3003
DOI:10.1016/j.bmc.2019.05.002
28.
Endo, Y.; Sugiura, Y.; Funasaki, M.; Kagechika, H.; Ishibashi, M.;
Ohsaki, A. "Two new alkaloids from Crinum asiaticum var. japonicum" J. Nat. Med. 2019, 73, 648-652 DOI:10.1007/s11418-019-01304-9
29.
Arai, M. A.; Ochi, F.; Makita,
Y.; Chiba, T.; Higashi, K.; Suganami, A.; Tamura, Y.; Toida, T.; Iwama, A.;
Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "GLI1
inhibitors isolated by target protein oriented natural products isolation
(TPO-NAPI) with hedgehog inhibition" ACS Chemical Biology
2018, 13, 2551-2559 DOI:10.1021/acschembio.8b00492 (*selected as
a cover art gallery)
30.
Hara, Y.; Arai, M. A.; Toume,
K.; Masu, H.; Sato, T.; Komatsu, K.; Yaguchi, T.; Ishibashi, M. "Coculture of a pathogenic actinomycete and animal cells to produce
nocarjamide, a cyclic nonapeptide with Wnt signal-activating effect" Org. Lett. 2018, 20, 5831-5834 DOI:10.1021/acs.acs.orglett.8b02522
31.
Hara, S.; Hara, Y.; Arai, M. A.; Kusuya, Y.; Takahashi, H.; Yaguchi,
T.; Ishibashi, M. "Isolation of nabscessin C from Nocardia abscessus IFM 10029T and a study on
biosynthetic pathway for nabscessins" Chem. Pharm. Bull. 2018, 66, 976-982 DOI:10.1248/cpb.c18-00430
32.
Arai, M. A.; Masuda, A.; Suganami, A.; Tamura, Y.; Ishibashi, M.
"Synthesis and evaluation of
fuligocandin B derivatives with TRAIL resistance overcoming activity" Chem. Pharm. Bull. 2018, 66, 810-817 DOI:10.1248/cpb.c18-00308 (*selected as
a cover article)
33.
Arai, M. A.; Akamine, R.;
Hayashi, N.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "The Notch inhibitors isolated from Nerium indicum" J. Nat. Prod. 2018, 81, 1235-1240 DOI:10.1021/acs.jnatprod.7b01031
34.
Arai, M. A.; Akamine, R.;
Tsuchiya, A.; Yoneyama, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "The Notch inhibitor cowanin
accelerates nicastrin degradation" Sci. Rep. 2018, 8, 5376 DOI:10.1038/s41598-018-23698-4
35.
Sampei, M.; Arai, M. A.; Ishibashi, M. "Synthesis of lignan glycosides with antioxidant activity" J. Nat. Med. 2018, 72, 651-654 DOI:10.1007/s11418-018-1198-6
Shareable Link: http://rdcu.be/IkXk
36.
Seephonkai, P.; Ishikawa, R.; Arai, M. A.; Kowithayakorn, T.;
Koyano, T.; Ishibashi, M. "New flavanol dimers from the bark of Celtis tetranda and their
TRAIL resistance-overcoming activity"
Nat. Prod. Commun. 2018, 13, 427-430 DOI:10.1177/1934578X1801300412
37.
Taniguchi,
K.; Funasaki, M.; Kishida, A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.; Ohsaki,
A. "Two new coumarins and a new xanthone
from the leaves of Rhizophora mucronata" Bioorg. Med. Chem. Lett. 2018,
28, 1063-1066 DOI:10.1016/j.bmcl.2018.02.022
38.
Hara, Y.; Arai, M. A.; Sakai, K.; Ishikawa,
N.; Gonoi, T.; Yaguchi, T.; Ishibashi, M. "Dehydropropylpantothenamide isolated by a co-culture
of Nocardia tenerifensis IFM 10554T in the presence of animal cells" J. Nat. Med. 2018, 72, 280-289 DOI:10.1007/s11418-017-1161-y
Shareable
Link: http://rdcu.be/ArMQ
39.
Liu, X.; Arai, M. A.; Toume, K.; Ishibashi, M. "Isolation of resistomycin from a
terrestrial actinomycete with TRAIL resistance-overcoming activity" Nat. Prod. Commun. 2018, 13,
65-66 DOI:10.1177/1934578X1801300119
40.
Endo,
Y.; Kasahara, T.; Harada, K.; Kubo, M.; Etoh, T.; Ishibashi, M.; Ishiyama, A.;
Iwatsuki, M.; Otoguro, K.; Ōmura, S.; Akisue, G.; Hirano, T.; Kagechika, H.;
Fukuyama, Y.; Ohsaki, A. "Sucupiranins
A-L: furanocassane diterpenoids from the seeds of Bowdichia virgilioides"
J. Nat. Prod. 2017,
80, 3120-3127 DOI:10.1021/acs.jnatprod.7b00249
41.
Karmakar,
U. K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Boesenberols I-K, new isopimarane diterpenes from Boesenbergia pandurata with
TRAIL-resistance overcoming activity" Tetrahedron Lett. 2017, 58, 3838-3841 DOI:10.1016/j.tetlet.2017.08.055
42.
Yoneyama, T.; Arai, M. A.; Akamine, R.; Koryudzu, K.; Sadhu, S. K.;
Ahmed, F.; Itoh, M.; Okamoto, R.; Ishibashi, M. "New Notch
inhibitors from Calotropis gigantea
that induce neuronal differentiation of neural stem cells" J. Nat. Prod. 2017,
80, 2453-2461
DOI:10.1021/acs.jnatprod.7b00282
43.
Kaneta, Y.; Arai, M. A.; Ishikawa, N.; Toume, K.;
Koyano, T.; Kowithayakorn, T.; Chiba, T.;
Iwama, A.; Ishibashi, M. "Identification
of BMI1 promoter inhibitors from Beaumontia
murtonii and Eugenia operculata" J. Nat. Prod. 2017, 80, 1853-1859 DOI:10.1021/acs.jnatprod.7b00138
44.
Arai, M. A.; Yamaguchi, Y.; Ishibashi, M. "Total synthesis of
agalloside, isolated from Aquilaria
agallocha, by the 5-O-glycosylation
of flavan" Org. Biomol. Chem. 2017, 15, 5025-5032 DOI:10.1039/C7OB01004D
45.
Arai, M. A.; Utsumi, T.; Yanase, N.; Fujimatsu, T.; Ishibashi, M.
"Efficient synthesis of heterocyclic flavonoids with hedgehog signal
inhibitory activity" Chem. Pharm.
Bull. 2017, 65, 784-795 DOI:10.1248/cpb.c17-00305
46.
Abdelfattah, M. S.; Elmallah,
M. I. Y.; Mohamed, A. A.; Ishibashi, M. "Sharkquinone,
a new ana-quinonoid tetracene derivative from marine-derived Streptomyces sp. EGY1 with TRAIL
resistance-overcoming activity" J.
Nat. Med. 2017, 71, 564-569 DOI:10.1007/s11418-017-1086-5
47.
Arai, M. A.; Tanaka, M.;
Tanouchi, K.; Ishikawa, N.; Ahmed, F.; Sadhu, S. K.; Ishibashi, M. "Hes1 binding compounds isolated by Target Protein Oriented Natural
Products Isolation (TPO-NAPI)" J. Nat. Prod. 2017, 80, 538-543 DOI:10.1021/acs.jnatprod.6b01072
48.
Hara,
S.; Ishikawa,
N.; Hara, Y.; Nehira, T.; Sakai, K.; Gonoi, T.;
Ishibashi, M. "Nabscessins A and B, new aminocyclitol derivatives from Nocardia abscessus IFM 10029T" J. Nat. Prod. 2017, 80, 565-568 DOI:10.1021/acs.jnatprod.6b00935
49.
Yixizhuoma; Ishikawa, N.; Abdelfattah, M. S.; Ishibashi, M. "Elmenols C-H, new angucycline derivatives isolated from a
culture of Streptomyces sp. IFM 11490" J. Antibiot. 2017, 70, 601-606 DOI:10.1038/ja.2016.158
50.
Yoneyama,
T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Isolation and evaluation of hedgehog inhibitors
from Christmas grass (Themeda arguens)" Heterocycles 2017, 65, 210-222 DOI:10.3987/COM-16-S(S)4
51.
Ahmed, F.; Karmakar, U.
K.; Arai, M. A.; Ishikawa, N.; Sadhu, S. K.; Ishibashi, M. "Germacranolides from Enhydra fluctuans with TRAIL-resistance
abrogating activity" Nat. Prod. Commun. 2017, 12, 1169-1170 DOI:10.1177/1934578X1701200805
52.
Tragulpakseerojn, J.; Yamaguchi,
N.; Pamonsinlapatham, P.; Wetwitayaklung, P.; Yoneyama, T.; Ishikawa, N.;
Ishibashi, M.; Apirakaramwong, A. "Anti-proliferative effect of Moringa
oleifera Lam (Moringaceae) leaf extract on human colon cancer HCT116 cell line" Trop. J. Pharm. Res. 2017, 16, 371-378
53.
Arai, M. A.; Taguchi, S.;
Komatsuzaki, K.; Uchiyama, K.; Masuda, A.; Sampei, M.; Satoh, M.; Kado, S.;
Ishibashi, M. "VCP is a target of 5'-I Fuligocandin B and enhances TRAIL-resistance
in cancer cells"
ChemistryOpen 2016, 5, 574-579 DOI: 10.1002/open.201600081
54.
Karmakar,
U. K.;
Ishikawa, N.; Arai, M. A.; Ahmed, F.; Koyano, T.;
Kowithayakorn, T.; Ishibashi, M. "Boesenberols, pimarane diterpenes with
TRAIL resistance-overcoming activity from Boesenbergia
pandurata"
J. Nat. Prod. 2016,
79, 2075-2082 DOI:10.1021/acs.jnatprod.6b00424
55.
Shono, T.; Ishikawa, N.; Toume, K.; Arai, M.
A.; Masu, H.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Cerasoidine, a bis-aporphine alkaloid isolated
from Polyalthia cerasoides during
screening for Wnt signal inhibitors" J. Nat. Prod. 2016, 79, 2083-2088 DOI:10.1021/acs.jnatprod.6b00409
56.
Fujita,
K.; Sugiyama, R.; Nishimura, S.; Ishikawa, N.; Arai, M. A.; Ishibashi, M.;
Kakeya, H. "Stereochemical assignment and
biological evaluation of BE-14106 unveils the importance of one acetate unit
for the antifungal activity of polyene macrolactams" J.
Nat. Prod. 2016, 79, 1877-1880 DOI:10.1021/acs.jnatprod.6b00250
57.
Arai, M. A.; Kofuji, Y.;
Tanaka, Y.; Yanase, N.; Yamaku, K.; Fuentes, R. G.; Karmakar, U. K.; Ishibashi,
M. "Synthesis of rocaglamide derivatives and evaluation of their Wnt
signal inhibitory activities" Org. Biomol. Chem. 2016, 14, 3061-3068 DOI:10.1039/c5ob02537k
58.
Ahmed, F.; Toume, K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ishibashi, M. "Constituents
from Entada scandens with
TRAIL-resistance overcoming activity" Nat. Prod. Commun. 2016, 11, 993-995 DOI:10.1177/1934578X1601100731
59.
Abdelfattah,
M. S.; Ishikawa, N.; Karmakar, U. K.; Yamaku, K.; Ishibashi, M. "New phenazine analogues from Streptomyces sp.
IFM 11694 with TRAIL resistance-overcoming activities" J.
Antibiot. 2016, 69, 446-450 DOI:10.1038/ja.2015.129
60.
Karmakar,
U. K.; Toume,
K.; Ishikawa, N.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.;
Ishibashi, M. "Bioassay-guided isolation of compounds with TRAIL-resistance
overcoming activity from Datura
stramonium"
Nat. Prod.
Commun. 2016, 11, 185-187 DOI:10.1177/1934578X1601100213
61.
Arai, M. A.; Ishikawa, N.; Tanaka, M.; Uemura, K.;
Sugimitsu, N.; Suganami, A.; Tamura, Y.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M. "Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of
differentiation activators of neural stem cells" Chem.
Sci. 2016, 7, 1514-1520 DOI:10.1039/c5sc03540f
62.
Abdelfattah,
M. S.; Ishikawa, N.; Karmakar, U. K.; Ishibashi, M. "Sulfotanone, a new alkyl sulfonic acid derivative from Streptomyces sp.
IFM 11694 with TRAIL resistance-overcoming activity" J.
Nat. Med. 2016, 70, 266-270 DOI:10.1007/s11418-015-0951-3
63.
Yixizhuoma; Tsukahara, K.; Toume, K.; Ishikawa,
N.; Abdelfattah, M. S.; Ishibashi, M. "Novel
cytotoxic isobenzofuran derivatives from Streptomyces sp. IFM 11490" Tetrahedron Lett. 2015, 56, 6345-6347 DOI:10.1016/j.tetlet.2015.09.116
64.
Ohishi,
K.; Toume,
K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.
"Coronaridine, an iboga type alkaloid from Tabernaemontana
divaricata, inhibits Wnt signaling pathway by decreasing β-catenin mRNA expression" Bioorg. Med. Chem. Lett. 2015,
25, 3937-3940 DOI:10.1016/j.bmcl.2015.07.036
65.
Yoneyama,
T.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.
"Hedgehog inhibitors from Withania somnifera" Bioorg. Med. Chem. Lett. 2015, 25, 3541-3544 DOI:10.1016/j.bmcl.2015.06.081
66.
Karmakar,
U. K.;
Ishikawa, N.; Toume, K.; Arai, M. A.; Sadhu, S. K.;
Ahmed, F.; Ishibashi, M. "Sesquiterpenes with TRAIL-resistance
overcoming activity from Xanthium strumarium" Bioorg.
Med. Chem. 2015, 23, 4746-4754 DOI:10.1016/j.bmc.2015.05.044
67.
Arai, M. A.; Uchida, K.; Sadhu,
S. K.; Ahmed, F.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Hedgehog inhibitors from Artocarpus
communis and Hyptis suaveolens" Bioorg. Med. Chem. 2015, 23, 4150-4154 DOI:10.1016/j.bmc.2015.06.058
68.
Arai, M. A.; Akamine, R.;
Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Hedgehog/GLI- mediated
transcriptional activity inhibitors from Crinum
asiaticum"
J. Nat. Med. 2015,
69, 538-542 DOI:10.1007/s11418-015-0922-8
69.
Shono,
T.; Ishikawa,
N.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.;
Ishibashi, M. "Boehmenan, a lignan, isolated from Hibiscus ficulneus showed Wnt signal
inhibitory activity"
Bioorg. Med. Chem. Lett. 2015,
25, 2735-2738 DOI:10.1016/j.bmcl.2015.05.037
70.
Fuentes,
R. G.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Phenolic compounds from the bark of Oroxylum indicum identified as Ngn2 promoter
activators"
J. Nat. Med. 2015,
69, 589-594 DOI:10.1007/s11418-015-0919-3
71.
Ohishi, K.; Toume, K.; Arai, M. A.; Koyano,
T.; Kowithayakorn, T.; Mizoguchi, T.; Itoh, M.; Ishibashi, M. "9-Hydorxycanthin-6-one, a β-carboline alkaloid
from Eurycoma longifolia, is the
first Wnt signal inhibitor through activation of GSK3β without depending on
CK1α" J. Nat. Prod. 2015, 78, 1139-1146 DOI:10.1021/acs.jnatprod.5b00153
72.
Fuentes,
R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Scopadulciol, isolated from Scoparia dulcis, induces β-catenin
degradation and overcomes tumor
necrosis factor-related apoptosis ligand resistance in AGS human gastric adenocarcinoma
cells" J. Nat. Prod. 2015, 78, 864-872
DOI:10.1021/np500933v
73.
Fuentes,
R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Limonoids with Wnt signal inhibitory activity isolated from the
fruits of Azadirachta excelsa" Phytochem. Lett. 2015, 11, 280-285 DOI:10.1016/j.phytol.2015.01.015
74.
Arai, M. A.; Koryudzu, K.; Ishibashi, M. "Inubosin A, B, and C are new acridine alkaloids isolated from Streptomyces sp. IFM 11440 that show
Ngn2 promoter activity" J. Nat. Prod. 2015, 78, 311-314 DOI:10.1021/np5006218
75.
Toume, K.; Habu, T.; Arai, M.
A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Prenylated
flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance" J. Nat. Prod. 2015, 78, 103-110 DOI:10.1021/np500734t; correction: J. Nat. Prod. 2015, 78, 968 DOI:10.1021/acs.jnatprod.5b00061
76.
Arai, M. A.; Uemura, K.; Hamahiga, N.; Ishikawa, N.;
Koyano, T.; Kowithayakorn, T.; Kaddar, T.; Carreau, M.; Ishibashi, M. "Naturally occurring FANCF-Hes1 complex
inhibitors from Wrightia religiosa" Med. Chem. Commun. 2015, 6, 455-460 DOI:10.1039/C4MD00495G
77.
Tahmina,
H.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Isolation of alkamides with death receptor-enhancing activities from
Piper chaba" Heterocycles
2015, 90, 1317-1322 DOI:10.3987/COM-14-S(K)68
78.
Tsukahara, K.; Toume, K.; Ito, H.; Ishikawa,
N.; Ishibashi, M. "Isolation of β-indomycinone guided by cytotoxicity tests from Streptomyces sp. IFM11607 and revision
of its double bond geometry" Nat. Prod. Commun. 2014, 9,
1327-1328 DOI:10.1177/1934578X1400900927
79.
Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu,
S. K.; Ahmed, F.; Mizoguchi, T.; Itoh, M.; Ishibashi, M. "Ricinine: a pyridone alkaloid from
Ricinus communis that activates the Wnt signaling pathway through casein kinase
1α" Bioorg. Med. Chem. 2014, 22, 4597-4601 DOI:10.1016/j.bmc.2014.07.027
80.
Toume, K.; Tsukahara, K.; Ito, H.; Arai, M.
A.; Ishibashi, M. "Chromomycins A2 and A3 from marine actinomycete with TRAIL
resistance-overcoming activity and Wnt signal inhibitory activity" Mar. Drugs 2014, 12, 3466-3476 DOI:10.3390/md12063466
81.
Park, H.-Y.;
Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Calotropin: a cardenolide from Calotropis gigantea that
inhibits Wnt signaling by
increasing casein kinase 1α in colon cancer cells" ChemBioChem
2014, 15, 872-878 DOI:
10.1002/cbic.201300786
82.
Arai, M. A.; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Physalin H from Solanum nigrum as Hh signaling inhibitor blocks GLI1-DNA complex
formation"
Beil. J. Org. Chem. 2014, 10, 134-140 DOI:10.3762/bjoc.10.10
83.
Fuentes,
R. G.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
"Constitutents from the rhizomes of Curcuma comosa and their Wnt signal inhibitory activity" Heterocycles 2014, 88, 1501-1509 DOI:10.3987/COM-13-S(S)49
84.
Park, H.-Y.;
Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M. "β-sitosterol and flavonoids isolated from Bauhinia malabarica found in a screening program for Wnt signal inhibitory activity" J. Nat. Med. 2014, 68, 242-245 DOI:
10.1007/s11418-013-0762-3
85.
Toume, K.; Kamiya, K.; Arai, M. A.; Mori,
N.; Sadhu, S. K.; Ahmed, F.;
Ishibashi, M. "Xylogranin
B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatum" Org. Lett. 2013, 15, 6106-6109 DOI:10.1021/ol4029995
86.
Minakawa, T.;
Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M. "Prenylflavonoids isolated from Artocarpus
champeden with TRAIL-resistance overcoming activity" Phytochemistry
2013, 96, 299-304 DOI:10.1016/j.phytochem.2013.08015; correction: Phytochemistry 2014, 106, 207 DOI:
10.1016/j.phytochem.2014.06.005
87.
Arai, M. A.; Koryudzu, K.; Koyano, T.;
Kowithayakorn, T.; Ishibashi, M. "Naturally
occurring Ngn2 promoter activators from Butea
superba"
Mol. BioSyst. 2013, 9, 2489-2497 DOI:10.1039/C3MB70083F
88.
Arai, M. A.; Fujimatsu, T.; Uchida, K.; Sadhu, S. K.;
Ahmed, F.; Ishibashi, M. "Hh signaling inhibitors from Vitex negundo, naturally occurring inhibitor of GLI1-DNA complex" Mol.
BioSyst. 2013, 9,
1012-1018 DOI:10.1039/C3MB25567K
89.
Arai, T.; Yamamoto, Y.; Awata, A.; Kamiya, K.;
Ishibashi, M.; Arai, M. A. "Catalytic asymmetric synthesis of mixed
3,3’-bisindoles and their evaluation as Wnt signaling inhibitors" Angew. Chem. Int. Ed. 2013, 52, 2486-2490 DOI:10.1002/anie.201208918
90.
Tamai, Y.;
Toume, K.; Arai, M. A.; Ishibashi, M. "Griseoviridin and cyclic hydroxamates found in a
screening program for Wnt signal inhibitor" Heterocycles
2012, 86, 1517-1524 DOI:10.3987/COM-12-S(N)64
91.
Minakawa, T.; Toume, K.; Arai,
M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M. "Eudesmane-type
sesquiterpenoid and guaianolides from Kandelia
candel in a screening program for compounds to overcome TRAIL-resistance" J. Nat. Prod. 2012, 75, 1431-1435 DOI:10.1021/np300179c; correction: J. Nat. Prod. 2014, 77, 437-437 DOI:10.1021/np5001208
92.
Toume, K.; Nakazawa, T.;
Tahmina, H.; Ohtsuki, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M. "Cycloartane triterpenes and ingol diterpenes isolated from Euphorbia
neriifolia in a screening program for death-receptor expression-enhancing
activity" Planta medica 2012, 78, 1370-1377 DOI:10.1055/s-0032-1314975
93.
Abdelfattah, M. S.; Toume, K.; Arai, M. A.; Masu, H.;
Ishibashi, M. "Katorazone, a novel yellow pigment with 2-azaquinone-phenylhydrazone
structure produced by Streptomyces
sp. IFM 11299"
Tetrahedron Lett. 2012, 53, 3346-3348 10.1016/j.tetlet.2012.04.073
94.
Abdelfattah, M. S.; Toume, K.; Ishibashi, M. "Yoropyrazone, a new naphthopyridazone alkaloid isolated from Streptomyces sp. IFM 11307 and
evaluation of its TRAIL resistance-overcoming activity" J. Antibiot. 2012,
65, 245-248 DOI:10.1038/ja.2012.11
95.
Yamaguchi, T.;
Toume, K.; Arai, M. A.; Ahmed, F.; Sadhu, S. K.;
Ishibashi, M.
"Phorbol esters with Wnt signal-augmenting effects
isolated from Excoecaria indica" Nat. Prod. Commun. 2012,
7, 475-477 DOI:10.1177/1934578X1200700414
96.
Koryudzu, K.; Arai, M. A.; Ahmed, F.; Sadhu, S.
K.; Ishibashi, M. "A new resin glycoside from Ipomoea maxima" Nat.
Prod. Commun. 2012,
7, 219-220 DOI:10.1177/1934578X1200700226
97.
Tamai, Y.;
Toume, K.; Arai, M. A.; Hayashida, A.; Kato, H.;
Shizuri, Y.; Tsukamoto, S.; Ishibashi, M. "Nonactin and related compounds found in a
screening program for Wnt signal inhibitory activity" Heterocycles
2012, 84,
1245-1250 DOI:10.3987/COM-11-S(P)18
98.
Abdelfattah, M. S.; Toume, K.; Ishibashi, M. "New pyranonaphthoquinones and phenazine alkaloid
isolated from Streptomyces sp. IFM 11307 with TRAIL
resistance-overcoming activity" J. Antibiot. 2011, 64, 729-734 DOI:10.1038/ja.2011.85; corrigendum, J. Antibiot. 2012, 65, 277 DOI:10.1038/ja.2012.25
99.
Rifai, Y.; Arai,
M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Acoschimperoside P,
2’-acetate: a Hedgehog signaling inhibitory constituent
from Vallaris glabra" J. Nat. Med. 2011, 65, 629-632 DOI:
10.1007/s11418-011-0530-1
100. Abdelfattah, M. S.; Toume,
K.; Ishibashi, M.
"Izumiphenazine D, new phenazoquinoline N-oxide
from Streptomyces sp. IFM 11204" Chem. Pharm. Bull. 2011, 59, 508-510 DOI:10.1248/cpb.59.508
101. Toume, K.; Nakazawa, T.; Ohtsuki, T.; Arai, M. A.; Koyano, T.;
Kowithayakorn, T.; Ishibashi, M. "Cycloartane triterpenes isolated from
Combretum quadrangulare in a screening program for death-receptor
expression enhancing activity" J. Nat. Prod. 2011, 74, 249-255 DOI:10.1021/np100784t
102. Abdelfattah, M. S.; Toume,
K.; Ishibashi, M. "Isolation and structure elucidation of izuminosides A-C: a rare
phenazine glycosides from Streptomyces sp. IFM 11260" J. Antibiot. 2011, 64,
271-275 DOI:10.1038/ja.2010.172
103. Ippongi, Y.; Ohtsuki, T.; Toume, K.; Arai, M. A.; Yamamoto, Y.;
Ishibashi, M. "Tubiferic acid, a new 9,10-secocycloartane triterpenoid acid
isolated from the myxomycete Tubulifera arachnoidea" Chem. Pharm. Bull. 2011, 59,
279-281 DOI:10.1248/cpb.59.279
104. Arai, M. A.; Tateno, C.; Koyano, T.; Kowithayakorn, T.; Kawabe, S.;
Ishibashi, M.
"New Hedgehog/GLI-signaling inhibitors from Adenium obesum" Org.
Biomol. Chem. 2011, 9, 1133-1139 DOI:10.1039/c0OB00677G
105. Rifai, Y.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.;
Ishibashi, M.
"New Hedgehog/GLI signaling inhibitors from
Excoecaria agallocha" Bioorg. Med. Chem. Lett. 2011,
21, 718-722 DOI:10.1016/j.bmcl.2010.11.126
106. Mori, N.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M.
"2-Methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening
program for activity to inhibit Wnt signaling" J.
Nat. Med. 2011, 65, 234-236 DOI:
10.1007/s11418-010-0471-0
107. Ahmed, F.; Toume, K.; Ohtsuki, T.; Rahman, M.; Sadhu, S. K.;
Ishibashi, M. "Cryptolepine, isolated from Sida acuta, sensitizes human
gastric adenocarcinoma cells to TRAIL-induced apoptosis" Phytotherapy
Research 2011,
25, 147-150 DOI:10.1002/ptr.3219
108. Brown, J. B.; Urata, T.; Tamura, T.; Arai, M.
A.; Kawabata, T.; Akutsu, T. "Compound analysis via graph kernels incorporating chirality" J. Bioinformatics Comput. Biol. 2010, 8,
63-81
109. Abdelfattah, M. S.; Toume,
K.; Ishibashi, M. "Izumiphenazines A−C: Isolation and structure elucidation of
phenazine derivatives from Streptomyces sp. IFM 11204" J. Nat. Prod. 2010, 73,
1999-2002 DOI:10.1021/np100400t
110. Shintani, A.; Toume, K.; Rifai, Y.; Arai, M. A.; Ishibashi, M. "A bisindole alkaloid with hedgehog signal inhibitory activity from
the myxomycete Perichaena chrysosperma" J.
Nat. Prod. 2010, 73, 1711-1713 DOI:10.1021/np1002687
111. Minakawa, T.; Toume, K.; Ahmed, F.; Sadhu, S. K.; Ohtsuki, T.; Arai,
M. A.; Ishibashi, M. "Constituents of Pongamia pinnata
isolated in a screening for activity to overcome TRAIL-resistance" Chem. Pharm. Bull. 2010, 58, 1549-1551 DOI:10.1248/cpb.58.1549
112. Arai, M. A.; Hanazawa, S.; Uchino, Y.; Li, X.; Ishibashi, M. "Total synthesis and evaluation of Wnt signal inhibition of melleumin
A and B, and their derivatives" Org. Biomol. Chem. 2010, 8, 5285-5293 DOI:10.1039/c0OB00352B
113. Arai, M. A.; Seto, J.; Ahmed, F.; Uchiyama, K.; Ishibashi, M. "Practical total synthesis of fuligocandins A and B" Synlett 2010, 2498-2502 DOI: 10.1055/s-0030-1258547
114. Ahmed, F.; Toume, K.; Sadhu, S. K.; Ohtsuki, T.; Arai, M. A.;
Ishibashi, M. "Constituents of Amoora cucullata with TRAIL resistance
overcoming activity"
Org. Biomol. Chem. 2010,
8, 3696-3703 DOI:10.1039/c004927a (*selected as a “Hot article”)
115. Abdelfattah, M. S.; Toume,
K.; Ahmed, F.; Sadhu, S. K.; Ishibashi, M. "Cucullamide, a new putrescine
bisamide from Amoora
cucullata"
Chem. Pharm. Bull. 2010,
58, 1116-1118 DOI:10.1248/cpb.58.1116
116. Maekawa, K.; Toume, K.; Ishibashi, M. "Isolation
of new fuzanins, carbamate-containing natural products, from Kitasatospora sp. IFM10917" J. Antibiot. 2010, 63,
385-388 DOI:10.1038/ja.2010.54
117. Shintani, A.; Toume, K.; Yamamoto, Y.; Ishibashi, M. "Dehydrofuligoic acid, a new yellow pigment isolated from the
myxomycete Fuligo septica f. flava" Heterocycles 2010, 82, 839-842 DOI:10.3987/COM-10-S(E)18
118. Rifai, Y.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
"Terpenoids and flavonoid glycoside from Acacia pennata as
Hedgehog/GLI-mediated transcriptional inhibitors" J.
Nat. Prod. 2010, 73,
995-997 DOI:10.1021/np1000818
119. Mizuoka, T.; Toume, K.; Ishibashi, M.; Hoshino, T. "Novel tryptophan metabolites, chromoazepinone A, B and C, produced
by a blocked mutant of Chromobacterium violaceum, the biosynthetic
implications and the biological activity of chromoazepinone A and B" Org. Biomol. Chem. 2010, 8,
3157-3163 DOI:10.1039/c003837g
120. Ohtsuki, T.; Miyagawa, T.; Koyano, T.; Kowithayakorn,
T.; Ishibashi, M.
"Isolation, structure elucidation, and
TRAIL-resistance-overcoming activity of flavonoid glycosides from Solanum verbascifolium" Phytochem. Lett. 2010, 3, 88-92 DOI:10.1016/j.phytol.2010.02.002
121. Kikuchi, H.; Ohtsuki, T.; Koyano, T.;
Kowithayakorn, T.; Sakai, T.; Ishibashi, M. "Activity
of mangosteen xanthones and teleocidin A-2 in death-receptor expression
enhancement and tumor necrosis-factor related apoptosis-inducing ligand assays" J. Nat. Prod. 2010, 73,
452-455 DOI:10.1021/np900404e
122. Ahmed, F.; Sadhu, S. K.; Ohtsuki, T.; Khatun, A.;
Ishibashi, M. "Glycosides from Vallaris solanaceae with
TRAIL-resistance-overcoming activity" Heterocycles 2010, 80, 477-488 DOI:10.3987/COM-09-S(S)52
123. Arai, M. A.; Kobatake, E.; Koyano, T.; Kowithayakorn, T.; Kato, S.; Ishibashi, M. "A method for the rapid discovery of
naturally occurring products by proteins immobilized on magnetic beads and
reverse affinity chromatography" Chem.
Asian J. 2009, 4, 1802-1808 DOI:10.1002/asia.200900357
124. Arai, M. A.; Masada, A.; Ohtsuka, T.; Kageyama,
R.; Ishibashi, M. "The first Hes1 dimer inhibitors from
natural products" Bioorg. Med. Chem. Lett. 2009, 19, 5778-5781 DOI:10.1016/j.bmcl.2009.07.146
125. Ohtsuki, T.; Kikuchi, H.; Koyano, T.; Kowithayakorn,
T.; Sakai, T.; Ishibashi, M. "Death receptor 5 promoter-enhancing compounds
isolated from Catimbium speciosum and
their enhancement effect on TRAIL-induced apoptosis" Bioorg.
Med. Chem. 2009, 17, 6748-6754 DOI:10.1016/j.bmc.2009.07.041
126. Miyagawa, T.; Ohtsuki, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi,
M. "Cardenolide glycosides of Thevetia peruviana and triterpenoid
saponins of Sapindus emarginatus as TRAIL resistance-overcoming compounds" J. Nat. Prod. 2009, 72, 1507-1511 DOI:10.1021/np900202n
127. Miyagawa, T.; Ohtsuki, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi,
M. "Cassaine diterpenoid dimers isolated from Erythrophleum
succirubrum with TRAIL-resistance overcoming activity" Tetrahedron Lett. 2009, 50,
4658-4662 DOI:10.1016/j.tetlet.2009.05.113
128. Shintani, A.; Yamazaki, H.; Yamamoto, Y.; Ahmed, F.; Ishibashi,
M. "Cribrarione C, a naphthoquinone pigment from the myxomycete Cribraria
meylanii" Chem. Pharm.
Bull. 2009, 57,
894-895 DOI:10.1248/cpb.57.894
129. Sadhu, S. K.; Tamaki, M.; Ohtsuki, T.; Toume, K.; Koyano, T.; Kowithayakorn,
T.; Ishibashi, M. "Cadinane sesquiterpenes from Curcuma parviflora" J. Nat. Prod. 2009, 72, 782-783 DOI:10.1021/np800709k
130. Shintani, A.; Ohtsuki, T.; Yamamoto, Y.; Hakamatsuka, T.;
Kawahara, N.; Goda, Y.; Ishibashi, M. "Fuligoic acid, a new yellow pigment
with a chlorinated polyene-pyrone acid structure isolated from the myxomycete Fuligo
septica f. flava" Tetrahedron Lett. 2009, 50, 3189-3190 DOI:10.1016/j.tetlet.2009.01.122
131. Ito, Y.; Kamo, S.; Sadhu, S. K.; Ohtsuki, T.; Ishibashi, M.; Kano,
Y. "Structure of new monoterpene glycoside from Sibiraea angustata Rchd. and its anti-obestic effect" Chem. Pharm. Bull. 2009, 57,
294-297 DOI:10.1248/cpb.57.294
132. Kikuchi, H.; Ohtsuki, T.; Koyano, T.;
Kowithayakorn, T.; Sakai, T.; Ishibashi, M. "Death receptor 5
targeting activity-guided isolation of isoflavones from Millettia
brandisiana and Ardisia colorata and evaluation of ability to induce
TRAIL-mediated apoptosis" Bioorg. Med. Chem. 2009, 17, 1181-1186 DOI:10.1016/j.bmc.2008.12.033
133. Li, Xiaofan; Ohtsuki, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
"New Wnt/β-catenin signaling
inhibitors isolated from Eleutherine
palmifolia"
Chem. Asian J. 2009, 4, 540-547 DOI:10.1002/asia.200800354
134. Aida, W.;
Ohtsuki, T.; Li, X.; Ishibashi, M. "Isolation of new carbamate- or pyridine-containing
natural products, fuzanins A, B, C, and D from Kitasatospora sp. IFM10917" Tetrahedron 2009, 65, 369-373 DOI:10.1016/j.tet.2008.10.040
135. Ohtsuki, T.; Hiraka, T.; Kikuchi, H.; Koyano, T.;
Kowithayakorn, T.; Sakai, T.; Ishibashi, M. "Flavonoids
from Eupatorium odoratum with death receptor 5 promoter enhancing
activity"
Heterocycles 2009, 77, 1379-1388 DOI:10.3987/COM-08-S(F)79
136. Ahmed, F.; Ohtsuki, T.; Aida, W.; Ishibashi, M. "Tyrosine derivatives isolated from Streptomyces sp. IFM 10937
in a screening program for TRAIL-resistance
overcoming activity"
J. Nat. Prod. 2008, 71, 1963-1966 DOI:10.1021/np8004248
137. Arai, M. A.;
Tateno, C.; Hosoya, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana" Bioorg. Med. Chem. 2008, 16,
9420-9424 
DOI:10.1016/j.bmc.2008.09.053
138. Arai, M. A.; Sato, M.; Sawada, K.; Hosoya, T.; Ishibashi, M. "Efficient Synthesis of Chromone and Flavonoid
Derivatives with Diverse Heterocyclic Units" Chem.
Asian J. 2008, 3, 2056-2064 DOI:10.1002/asia.200800166
139. Arai, M. A.; Uchino, Y.; Hanazawa, S.; Li, X.; Kimura, N.; Ishibashi, M. "Synthesis and evaluation of isomers of melleumin B from the
myxomycete Physarum melleum; an
approach for Wnt signal inhibitor trusted in nature" Heterocycles 2008, 76,
1425-1438 DOI:10.3987/COM-08-S(N)108
140. Sadhu, S. K.; Khatun, A.;
Ohtsuki, T.; Ishibashi, M. "Constituents from Hoya parasitica and their cell growth
inhibitory activity"
Planta Medica 2008,
74, 760-763 DOI:10.1055/s-2008-1074523
141. Ohtsuki, T.; Miyagawa, T.; Koyano, T.; Kowithayakorn,
T.; Kawahara, N.; Goda, Y.; Ishibashi, M. "Acylated
triterpenoid saponins from Schima noronhae and their cell growth
inhibitory activity" J. Nat. Prod. 2008, 71, 918-921 DOI:10.1021/np800036t
142. Hosoya, T.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. "Naturally occurring small-molecule inhibitors of
Hedgehog/GLI-mediated transcription" ChemBioChem 2008, 9, 1082-1092 DOI:
10.1002/cbic.200700511 (*selected as “Most accessed articles
2/2008-1/2009”)
143. Ohtsuki, T.; Tamaki, M.; Toume, K.; Ishibashi, M. "A novel sesquiterpenoid dimer
parviflorene F induces apoptosis by upregulating the expression of TRAIL-R2 and
a caspase-dependent mechanism" Bioorg. Med. Chem. 2008,
16, 1756-1763 DOI:10.1016/j.bmc.2007.11.022
144. Hanazawa, S.; Arai, M. A.; Li, X.; Ishibashi, M. "Determination
of absolute stereochemistry, total synthesis, and evaluation of peptides from
the myxomycete Physarum melleum" Bioorg. Med. Chem. Lett. 2008, 18, 95-98
DOI:10.1016/j.bmcl.2007.11.005
145. Ohtsuki, T.; Yokosawa, E.;
Koyano, T.; Preeprame, S.; Kowithayakorn, T.; Sakai, S.; Toida, T.; Ishibashi, M. "Quinic
acid esters from Pluchea indica with collagenase, MMP-2, and MMP-9
inhibitory activity" Phytotherapy Research 2008, 22, 264-266 DOI:10.1002/ptr.2290
146. Kikuchi, H.; Ohtsuki, T.; Koyano, T.; Kowithayakorn, T.; Sakai, T.;
Ishibashi, M.
"Brandisianins A-F, isoflavonoids isolated from Millettia brandisiana in a screening
program for death-receptor expression enhancement activity" J. Nat. Prod. 2007, 70, 1910-1914 DOI:10.1021/np0703904
147. Li, X.;
Ohtsuki, T.; Shindo, S.; Sato, M.; Koyano, T.; Preeprame, S.; Kowithayakorn, T.; Ishibashi, M. "Mangiferin identified in a screening study guided by neuraminidase inhibitory activity" Planta Medica 2007, 73, 1195-1196 DOI:10.1055/s-2007-981582
148. Hasegawa, H.; Yamada, Y.;
Komiyama, K.; Hayashi, M.; Ishibashi, M.; Sunazuka, T.;
Izuhara, T.; Sugahara, K.; Tsuruda, K.; Masuda, M.; Takasu, N.; Tsukasaki, K.;
Tomonaga, M.; Kamihira, S. "A novel natural compound, a
cycloanthranilylproline-derivative (Fuligocandin B), sensitizes leukemia cells
to TRAIL-induced apoptosis through 15d-PGJ2 production" Blood 2007, 110, 1664-1674 DOI:10.1182/blood-2007-01-068981
149. Sadhu, S. K.; Khatun, A.; Phattanawasin, P.; Ohtsuki,
T.; Ishibashi, M. "Lignan glycosides and flavonoids from Saraca asoca with antioxidant activity" J.
Nat. Med. 2007, 61, 480-482. DOI:10.1007/s11418-007-0182-3
150. Watanabe, K.; Ohtsuki, T.;
Yamamoto, Y.; Ishibashi, M. "New
kehokorins and trichiols from the myxomycete Trichia favoginea" Heterocycles 2007, 71,
1807-1814 DOI:10.3987/COM-07-11075
151. Kaniwa, K.; Arai, M. A.; Li, X.; Ishibashi, M. "Synthesis, determination of stereochemistry, and evaluation of new bisindole alkaloids from the myxomycete Arcyria ferruginea; an approach for Wnt signal inhibitor" Bioorg. Med. Chem. Lett. 2007, 17, 4254-4257 DOI:10.1016/j.bmcl.2007.05.033
152. Koranne, P. S.; Tsujihara, T.; Arai, M. A.; Bajracharya, G. B.; Suzuki, T.; Onitsuka, K.; Sasai, H. "Design and Synthesis of Chiral Hybrid Spiro(isoxazole-isoxazoline) Ligands" Tetrahedron: Asymmetry, 2007, 18, 919-923
153. Ohtsuki, T.; Kaneko, N.;
Koyano, T.; Kowithayakorn, T.; Kawahara, N.; Goda, Y.; Ishibashi, M. "Cell
growth and cell cycle inhibitory activeties of 20-epidiosgenyl saponin from Calamus insignis" Heterocycles 2007, 74, 931-936 DOI:10.3987/COM-07-S(W)2
154. Sadhu, S. K.; Khan, M. S.; Ohtsuki, T.; Ishibashi, M. "Secoiridoid
components from Jasminum grandiflorum" Phytochemistry 2007, 68, 1718-1721 DOI:10.1016/j.phytochem.2007.04.029
155. Sadhu, S. K.; Khatun, A.; Ohtsuki, T.; Ishibashi, M. "First isolation of sesquiterpenes and flavonoids
from Zingiber spectabile and
identification of zerumbone as the major cell growth inhibitory component" Nat. Prod. Res. 2007, 21,
1242-1247 DOI:
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156. Arai, M. A.; Takeyama, K.; Ito, S.; Kato, S.; Chen, T. C.; Kittaka,
A. "High-throughput system for analyzing ligand-induced cofactor
recruitment by vitamin D receptor" Bioconjugate
Chemistry, 2007, 18, 614-620
157. Urushino, N.; Nakabayashi, S.; Arai, M.A.; Kittaka,
A.; Chen, T.C.; Yamamoto, K.; Hayashi, K.; Kato, S.; Ohta, M.; Kamakura, M.; Ikushiro, S.;
Sakaki, T. "Kinetic Studies of
25-Hydroxy-19-Nor-Vitamin D3 and 1α,25-Dihydroxy-19-Nor-Vitamin D3
Hydroxylation by CYP27B1 and CYP24A1"
Drug Metabolism and Disposition, 2007, 35, 1482-1488
158. Kittaka, A.; Saito, N.; Honzawa, S.; Takenouchi, K.; Ishizuka, S.;
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synthesis of novel vitamin D analogs for health and disease" J. Steroid Biochem. Mol.
Biol., 2007, 103, 269-276.
159. Wakita, K.; Bajracharya, G. B.; Arai, M. A.; Takizawa, S.; Suzuki,
T.; Sasai, H. "Enantioselective glyoxylate-ene reaction using a novel spiro
bis(isoxazoline) ligand in copper catalysis" Tetrahedron: Asymmetry, 2007, 18, 372-376
160. Chen, T. C.; Persons, K. S.; Zheng, S.; Mathieu, J.; Holick, M. F.;
Lee, Y. F.; Bao, B.; Arai, M. A.; Kittaka, A. "Evaluation
of C-2-substituted 19-nor-1a,25-dihydroxyvitamin D3 analogs as
therapeutic agents for prostate cancer" J.
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161. Tamaki, M.; Sadhu, S. K.;
Ohtsuki, T.; Toume, K.; Koyano, T.; Kowithayakorn, T.;
Ishibashi, M.
"Parviflorene J,
a cytotoxic sesquiterpene dimer with a new rearranged skeleton from Curcuma parviflora" Heterocycles 2007, 72, 649-654 DOI:10.3987/COM-06-S(K)2
162. Aoki, W.; Ohtsuki, T.; Sadhu, S. K.; Sato, M.; Koyano, T.;
Preeprame, S.; Kowithayakorn, T.; Ishibashi, M. "First
isolation of three diterpenes as naturally-occurring compounds from Sindora siamensis" J. Nat. Med. 2007, 61, 77-79 DOI:
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163. Arai, M.A.; Kittaka, A. "Novel 2-alkyl-1a,25-dihydroxy-19-norvitamin
D3: efficient synthesis with Julia olefination, evaluation of
biological activity, and development of new analyzing system on coactivator
recruitment" Anticancer Research, 2006,
26, 2621-2632
164. Hosoya, T.; Kato, Y.;
Yamamoto, Y.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "Tryptophan 4-aminocinnamamides
from a myxomycete Fuligo aurea" Heterocycles 2006, 69,
463-468 DOI:10.3987/COM-06-S(O)19
165. Kamata, K.; Suetsugu, T.;
Yamamoto, Y.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "Bisindole alkaloids from myxomycetes Arcyria denudata and Arcyria obvelata" J.
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166. Sadhu, S. K.; Okuyama, E.;
Fujimoto, H.; Ishibashi, M. "Diterpenes from Leucas aspera inhibiting
prostaglandin-induced contractions" J.
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167. Kaniwa, K.; Ohtsuki, T.;
Sonoda, T.; Yamamoto, Y.; Hayashi, M.; Komiyama, K.;
Ishibashi, M. "Trichiol and 3-epitrichiol acetate, novel cytotoxic sterols with a
2,6-dioxabicyclo[2.2.2]octan-3-one ring system from
the myxomycete Trichia favoginea var. persimilis" Tetrahedron Lett. 2006, 47,
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168. Sadhu, S. K.; Okuyama, E.; Fujimoto, H.; Ishibashi, M.;Yesilada, E. "Prostaglandin inhibitory and antioxidant components
of Cistus laurifolius,
a Turkish medicinal plant" Journal
of Ethnopharmacology 2006,
108, 371-378 DOI:
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169. Hasan, M. S.; Ahmed, M. I.; Mondal, S.; Uddin, S. J.; Masud, M. M.; Sadhu, S. K.; Ishibashi, M. "Antioxidant, antinociceptive activity
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170. Sadhu, S. K.; Hirata, K.;
Li, X.; Koyano, T.; Preeprame, S.; Kowithayakorn, T.; Ohtsuki, T.; Ishibashi, M. "Flavonoids and sesquiterpenoids
constituents from Eupatorium
capillifolium found in a screening study guided by cell growth inhibitory
activity"
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60, 325-328 DOI:
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171. Fujimoto, H.; Asai, T.;
Kim, Y.-P.; Ishibashi, M. "Nine
constituents including six xanthone-related compounds isolated from two
Ascomycetes, Gelasinospora santi-florii and Emericella quadrilineata,
found in a screening study focused on immunomodulatory activity" Chem. Pharm. Bull. 2006, 54,
550-553 DOI:
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172. Sadhu, S. K.; Phattanawasin,
P.; Choudhuri, M. S. K.; Ohtsuki, T.; Ishibashi, M. "A new lignan from Aphanamixis polystachya" J. Nat. Med. 2006, 60, 258-260 DOI:
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173. Kaniwa, K.; Ohtsuki, T.;
Yamamoto, Y.; Ishibashi, M. "Kehokorins
A-C, novel cytotoxic dibenzofurans isolated from the myxomycete Trichia
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174. Sadhu, S. K.; Ahmed, F.;
Ohtsuki, T.; Ishibashi, M. "Flavonoids
from Sonneratia caseolaris" J. Nat. Med. 2006, 60, 264-265 DOI:
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175. Hasegawa, H.; Yamada, Y.; Komiyama, K.; Hayashi, M.; Ishibashi, M.; Yoshida, T.; Sakai, T.; Koyano, T.; Kam, T.-S.; Murata K.; Sugahara, K.; Tsuruda, K.; Akamatsu, N.; Tsukasaki, K.; Masuda, M.; Takasu, N.; Kamihira S. "Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells" Blood 2006, 107, 679-688 DOI: 10.1182/blood-2005-05-1982
176. Ohtsuki, T.; Sato, M.;
Koyano, T.; Kowithayakorn, T.; Kawahara, N.; Goda, Y.;
Ishibashi, M.
"Steroidal
saponins from Calamus insignis and
their cell growth and cell cycle inhibitory activities" Bioorg.
Med. Chem. 2006, 14, 659-665 DOI:10.1016/j.bmc.2005.08.059
177. Seino-Umeda, A.; Ishibashi, M.; Kobayashi, J.; Ohizumi, Y. "Structure-activity relationship
for the Ca2+-releasing activity of 6-hydroxy-β-carboline analogues,
the caffeine-like Ca2+-releasers, in fragmented sarcoplasmic reticulum
of Skeletal Muscle"
Pharmacometrics 2005,
68, 139-143
178. Seino-Umeda, A.; Ishibashi, M.; Kobayashi, J.; Ohizumi, Y. "9-Methyl-7-bromoeudistomin D
interacts with ryanodine receptor in skeletal muscle sarcoplasmic reticulum as
a high affinity ligand of caffeine-binding site" Pharmacometrics 2005, 68, 129-137
179. Fujimoto, H.; Okamoto, Y.; Sone, E.; Maeda, S.; Akiyama, K.;
Ishibashi, M.
"Eleven new 2-pyrones from a fungi imperfecti, Trichurus
terrophilus,found
in a screening study guided by immunomodulatory activity" Chem. Pharm. Bull. 2005, 53, 923-929 DOI:10.1248/cpb.53.923
180. Toume, K.; Sato, M.;
Koyano, T.; Kowithayakorn, T.; Yamori, T.;
Ishibashi, M.
"Cytotoxic dimeric sesquiterpenoids from Curcuma parviflora:
isolation of three new parviflorenes and absolute stereochemistry of
parviflorenes A, B, D, F, and G" Tetrahedron
2005, 61, 6700-6706 DOI:10.1016/j.tet.2005.05.016
181. Teramachi, F.; Koyano, T.; Kowithayakorn, T.; Hayashi, M.;
Komiyama, K.; Ishibashi, M. "Collagenase inhibitory quinic acid
esters from Ipomoea pes-caprae" J. Nat. Prod. 2005, 68, 794-796 DOI: 10.1021/np0500631
182. Hosoya, T.; Yamamoto, Y.; Uehara, Y.; Hayashi, M.;
Komiyama, K.; Ishibashi, M. "New cytotoxic bisindole alkaloids with
protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum" Bioorg. Med. Chem. Lett. 2005, 15, 2776-2780 DOI:10.1016/j.bmcl.2005.03.103
183. Kamata, K.; Kiyota, M.; Naoe, A.; Nakatani, S.; Yamamoto, Y.;
Hayashi, M.; Komiyama, K.; Yamori, T.; Ishibashi, M. "New bisindole alkaloids isolated from myxomycetes Arcyria cinerea and Lycogala epidendrum" Chem. Pharm. Bull. 2005,
53, 594-597 DOI:10.1248/cpb.53.594
184. Osaki, N.; Koyano, T.; Kowithayakorn, T.; Hayashi, M.;
Komiyama, K.; Ishibashi, M. "Sesquiterpenoids and
plasmin-inhibitory flavonoids from Blumea balsamifera" J. Nat. Prod. 2005, 68, 447-449 DOI: 10.1021/np049622e
185. Akiyama, K.; Yamamoto, S.;
Fujimoto, H.; Ishibashi, M. "Total synthesis
of TT-1 (rasfonin), an α-pyrone-containing natural product from a fungus Trichurus terrophilus" Tetrahedron 2005, 61, 1827-1833 DOI:10.1016/j.tet.2004.12.013
186. Nakatani, S.; Kamata, K.;
Sato, M.; Onuki, H.; Hirota, H.; Matsumoto, J.;
Ishibashi, M.
"Melleumin A, a novel peptide lactone isolated
from the cultured myxomycete Physarum melleum" Tetrahedron
Lett. 2005, 46, 267-271 DOI:10.1016/j.tetlet.2004.11.053
187. Nakatani, S.; Kiyota, M.;
Matsumoto, J.; Ishibashi, M. "Pyrroloiminoquinone
pigments from Didymium iridis" Biochem. Sys. Ecol. 2005, 33, 323-325 DOI:10.1016/j.bse.2004.06.015
188. Toume, K.; Takahashi, M.;
Koyano, T.; Kowithayakorn, T.; Yamaguchi, K.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "Parviflorenes B - F, novel
cytotoxic unsymmetrical sesquiterpene-dimers with three
backbone skeletons from
Curcuma parviflora" Tetrahedron 2004, 60, 10817-10824 DOI:10.1016/j.tet.2004.09.043
189. Kamata, K.; Onuki, H.;
Hirota, H.; Yamamoto, Y.; Hayashi, M.; Komiyama, K.;
Sato, M.; Ishibashi, M. "Tubiferal A, a backbone-rearranged
triterpenoid lactone isolated from the myxomycete Tubifera dimorphotheca,
possessing reversal of drug resistance activity" Tetrahedron 2004, 60, 9835-9839 DOI:10.1016/j.tet.2004.08.071
190. Ohtsuki, T.; Koyano, T.; Kowithayakorn, T.; Yamaguchi, N.; Ishibashi, M. "Isolation of austroinulin possessing cell cycle inhibition activity
from Blumea glomerata and revision of its absolute configuration" Planta Medica 2004, 70,
1170-1173 DOI: 10.1055/s-2004-835847
191. Fujimoto, H.; Nakamura, E.; Okuyama, E.; Ishibashi, M. "Six immunosuppressive features from an ascomycete, Zopfiella
longicaudata, found in a screening study by immunomodulatory activity" Chem. Pharm. Bull. 2004, 52, 1005-1008 DOI:10.1248/cpb.52.1005
192. Ohtsuki, T.; Koyano, T.; Kowithayakorn, T.; Sakai, S.; Kawahara, N.; Goda, Y.; Yamaguchi, N.;
Ishibashi, M.
"New chlorogenin hexasaccharide isolated from Agave fourcroydes with cytotoxic and
cell cycle inhibitory activities " Bioorg. Med. Chem. 2004,
12, 3841-3845 DOI:10.1016/j.bmc.2004.05.004
193. Toume, K.; Miyata, M.; Egawa, K.; Nose, K.; Hayashi, M.;
Komiyama, K.; Ishibashi, M. "Isolation of
diphlorethohydroxycarmalol from a brown alga Ishige okamurae" Natural Medicines 2004, 58, 79-80
194. Chanmahasathien, W.; Li, Y.; Ishibashi, M.; Ruangrungsi, N.;
Ohizumi, Y.
"Xanthones with NGF-potentiating activity" Natural Medicines 2004, 58, 76-78.
195. Nakatani, S.; Yamamoto, Y.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "Cycloanthranilylproline-derived constituents from a myxomycete Fuligo
candida" Chem. Pharm. Bull. 2004,
52, 368-370 (*selected as a cover article)
DOI:10.1248/cpb.52.368
196. Fujimoto, H.; Sumino, M.; Okuyama, E.; Ishibashi, M. "Immunomodulatory constituents from an ascomycete, Chaetomium
seminudum" J. Nat. Prod. 2004, 67, 98-102 DOI: 10.1021/np0302201
197. Akiyama, K.; Kawamoto, S.; Fujimoto, H.; Ishibashi, M. "Absolute stereochemistry of TT-1 (rasfonin), an α-pyrone-containing
natural product from a fungus Trichurus
terrophilus" Tetrahedron Lett. 2003, 44, 8427-8431 DOI:10.1016/j.tetlet.2003.09.136
198. Iwata, D.; Ishibashi, M.; Yamamoto, Y. "Cribrarione
B, a new naphthoquinone pigment from the myxomycete Cribraria cancellata" J. Nat. Prod. 2003, 66, 1611-1612. DOI: 10.1021/np030308e
199. Chanmahasathien, W.; Li, Y.; Satake, M.; Oshima, Y.; Ishibashi, M.; Ruangrungsi, N.;
Ohizumi, Y.
"Prenylated xanthones from Garcinia xanthochymus" Chem. Pharm. Bull. 2003, 51, 1332-1334 DOI:10.1248/cpb.51.1332
200. Li, Y.; Ishibashi, M.; Satake, M.; Oshima, Y.; Ohizumi, Y. "A new iridoid
glycoside with nerve growth factor-potentiating activity, gelsemiol 6’-trans-caffeoyl-1-glucoside,
from Verbena littoralis" Chem. Pharm. Bull. 2003,
51, 1103-1105 DOI:10.1248/cpb.51.1103
201. Nakatani, S.; Naoe, A.; Yamamoto, Y.; Yamauchi, T.; Yamaguchi, N.;
Ishibashi, M.
"Isolation of bisindole alkaloids that inhibit the
cell cycle from myxomycetes Arcyria ferruginea and Tubifera casparyi" Bioorg. Med. Chem. Lett. 2003, 13, 2879-2881 DOI:10.1016/S0960-894X(03)00592-4
202. Misono, Y.; Ishikawa, Y.; Yamamoto, Y.; Hayashi, M.; Komiyama, K.;
Ishibashi, M.
"Dihydrolindbladiones, three new naphthoquinone
pigments from a myxomycete Lindbladia tubulina" J.
Nat. Prod. 2003, 66, 999-1001 DOI: 10.1021/np030089x
203. Li, Y.; Ishibashi, M.; Chen, X.; Ohizumi,
Y. "Littorachalcone, a new enhancer of
NGF-mediated neurite outgrowth, from Verbena littoralis" Chem. Pharm. Bull. 2003, 51, 872-874 DOI:10.1248/cpb.51.872
204. Misono, Y.; Ito, A.; Matsumoto, J.;
Sakamoto, S.; Yamaguchi, K.; Ishibashi, M. "Physarigins A-C, three new pigments from a cultured myxomycete Physarum
rigidum" Tetrahedron Lett. 2003, 44, 4479-4481 DOI:10.1016/S0040-4039(03)01041-4
205. Li, Y.; Ishibashi, M.; Satake, M.; Chen, X.; Oshima, Y.; Ohizumi, Y. "Sterol and triterpenoid
constituents of Verbena littoralis with NGF-potentiating activity" J. Nat. Prod.2003, 66, 696-698 DOI: 10.1021/np020577p
206. Kawamoto, S.; Koyano, T.; Kowithayakorn, T.; Fujimoto, H.; Okuyama,
E.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "Wrightiamines
A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica" Chem. Pharm. Bull. 2003, 51, 737-739. DOI:10.1248/cpb.51.737
207. Misono, Y.; Ishibashi, M.; Ito, A. "Bahiensol,
a new glycerolipid from a cultured myxomycete Didymium bahiense var. bahiense" Chem. Pharm. Bull. 2003, 51, 612-613 DOI:10.1248/cpb.51.612
208. Sadhu, S. K.; Okuyama, E.; Fujimoto, H.; Ishibashi, M. "Separation of Leucas aspera, a medicinal plant of Bangladesh,
guided by prostaglandin inhibitory and antioxidant activities" Chem. Pharm. Bull. 2003, 51, 595-598 DOI:10.1248/cpb.51.595
209. Naoe, A.; Ishibashi, M.; Yamamoto,
Y. "Cribrarione A, a new antimicrobial
naphthoquinone pigment from a myxomycete Cribraria purpurea" Tetrahedron 2003, 59,
3433-3435
DOI:10.1016/S0040-4020(03)00514-3
210. Fujimoto, H.; Nozawa, M.; Okuyama, E.; Ishibashi, M. "Six new constituents from an ascomycete, Chaetomium
quadrangulatum, found in a screening study focused on monoamine oxidase
inhibitory activity" Chem. Pharm. Bull. 2003, 51, 247-251
DOI:10.1248/cpb.51.247
211. Takahashi, M.; Koyano, T.; Kowithayakorn, T.; Hayashi, M.; Komiyama,
K.; Ishibashi, M.
"Parviflorene A, a Novel Cytotoxic Unsymmetrical
Sesquiterpene-Dimer Constituent from Curcuma parviflora" Tetrahedron Lett. 2003, 44, 2327-2329 DOI:10.1016/S0040-4039(03)00254-5
212. Tanaka, T.; Ishibashi, M.; Fujimoto, H.; Okuyama, E.; Koyano, T.;
Kowithayakorn, T.; Hayashi, M.; Komiyama, K. "New
onoceranoid triterpene constituents from Lansium domesticum" J. Nat. Prod. 2002, 65, 1709-1711 DOI: 10.1021/np020239o
213. Misono, Y.; Ishibashi, M.; Koyano, T.; Kowithayakorn, T.; Hayashi,
M.; Komiyama, K.
"A new secoiridoid constituent from Brucea
amarissima" Natural Medicines 2002, 56, 150-152
214. Toume, K.; Ishibashi, M. "A 5α,8α-epidioxysterol
sulfate from a diatom Odontella aurita" Phytochemistry 2002, 61, 359-360 DOI:10.1016/S0031-9422(02)00224-8
215. Ishikawa, Y.; Ishibashi, M.; Yamamoto, Y.; Hayashi, M.; Komiyama, K. "Lindbladione and related naphthoquinone pigments from a myxomycete Lindbladia
tubulina" Chem. Pharm. Bull. 2002, 50, 1126-1127 DOI:10.1248/cpb.50.1126
216. Ishikawa, Y.; Misono, Y.; Nakatani, S.; Ito, A.; Matsumoto, J.;
Ishibashi, M.
"Laboratory cultures of myxomycetes: fruit body
formation in five species of the genus Didymium" J.
Nat. Hist. Mus. Inst., Chiba 2002,
7, 1-4
217. Fujimoto, H.; Nozawa, M.; Okuyama, E.; Ishibashi, M. "Five new chromones possessing monoamine oxidase inhibitory activity
from an ascomycete, Chaetomium quadrangulatum" Chem.
Pharm. Bull. 2002,
50, 330-336 DOI:10.1248/cpb.50.330
218. Masuda, D.; Koyano, T.; Fujimoto, H.; Okuyama, E.; Hayashi, M.;
Komiyama, K.; Ishibashi, M. "Alkenylphenol and alkenylsalicylic
acid from Mangifera caesia" Biochem. Sys. Ecol. 2002, 30, 475-478 DOI:10.1016/S0305-1978(01)00108-9
219. Ishikawa, Y.; Kono, Y.; Iwasaki, T.; Misono, Y.; Nakatani, S.;
Ishibashi, M.; Ito, A.; Matsumoto, J. "Formation of fruit bodies of
myxomycetes of the genus Didymium in plate cultures and identification
of glucoclionasterol from Didymium minus" Natural
Medicines 2001, 55, 312
220. Tanaka, T.; Koyano, T.; Kowithayakorn, T.; Fujimoto, H.; Okuyama,
E.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "New
multiflorane-type triterpenoid acids from Sandoricum indicum" J. Nat. Prod. 2001, 64, 1243-1245 DOI: 10.1021/np010196w
221. Fujimoto, H.; Nakamura, E.; Kim, Y.-P.; Okuyama, E.; Ishibashi, M.;
Sassa, T.
"Immunomodulatory
constituents from an ascomycete, Eupenicillium crustaceum, and revised
absolute structure of macrophorin D" J. Nat. Prod. 2001, 64,
1234-1237
DOI: 10.1021/np010152n
222. Sakio, Y.; Hirano, Y. J.; Hayashi, M.; Komiyama, K.; Ishibashi, M. "Dendocarbins A ~ N, new drimane sesquiterpenes from the nudibranch Dendrodoris
carbunculosa" J. Nat. Prod. 2001, 64, 726-731 DOI: 10.1021/np000639g
223. Toume, K.; Ishibashi, M.; Miyata, M. "A study on chemical constituents of three red algae of the
Corallinaceae from Boso Peninsula in Japan" Nat. Hist. Res. 2001,
6, 39-42
224. Li, Y.; Matsunaga, K.; Ishibashi, M.; Ohizumi, Y. "Littoralisone, a novel neuritogenic iridolactone having
unprecedented heptacyclic skeleton including four- and nine-membered rings
consisting of glucose from Verbena
littoralis" J. Org. Chem. 2001, 66, 2165-2167 DOI: 10.1021/jo001460d
225. Okuyama, E.; Hasegawa, T.;
Matsushita, T.; Fujimoto, H.; Ishibashi, M.; Yamazaki, M. "Analgesic components of Saposhnikovia root (Saposhnikovia
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Chem. Pharm. Bull. 2001, 49, 154-160 DOI:10.1248/cpb.49.154
226. Ishibashi, M.; Iwasaki, T.; Imai, S.; Sakamoto, S.; Yamaguchi, K.;
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"Laboratory culture of the myxomycetes: formation
of fruiting bodies of Didymium bahiense and its plasmodial production of
makaluvamine A" J. Nat. Prod. 2001,
64, 108-110 DOI: 10.1021/np000382m
227. Kubota, T.; Tsuda, M.;
Takahashi, M.; Ishibashi, M.; Oka, S.; Kobayashi, J. "Colopsinols D and E, new polyhydroxy linear carbon chain compounds
from marine dinoflagellate Amphidinium sp." Chem. Pharm. Bull. 2000,
48, 1447-1451
228. Fujimoto, H.; Nakamura, E.; Okuyama, E.; Ishibashi, M. "Immunomodulatory constituents from an ascomycete, Emericella
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229. Nakamura, M.; Ishibashi, M.; Okuyama, E.; Koyano, T.; Kowithayakorn,
T.; Hayashi, M.; Komiyama, K. "Cytotoxic pregnanes from the leaves
of Adenium obesum" Natural Medicines 2000, 54,
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230. Seino-Umeda, A.; Ishibashi,
M.; Kobayashi, J.; Ohizumi, Y. "Structure-activity relationships for the
Ca2+-releasing activity of 6-hydorxy-b-carboline analogues in
skeletal muscle sarcoplasmic reticulum – the effects of halogen substitution at
C-5 and C-6" J. Pharm. Pharmacol. 2000, 52, 517-521
231. Sakio, Y.; Ishibashi, M.;
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232. Kubota, T.; Tsuda, M.;
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233. Ishibashi,
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Medicines 1999, 53, 316-318
234. Okuyama,
E.; Homma, M.; Satoh, Y.; Fujimoto, H.; Ishibashi, M.; Yamazaki, M.; Satake,
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medicine" Chem. Pharm. Bull. 1999, 47, 1473-1476
235. Ishibashi,
M.; Oda, H.; Mitamura, M.; Okuyama, E.; Komiyama, K.; Kawaguchi, K.; Watanabe.
T.; de Mello Alves, S.; Maekawa, T.; Ohtsuki, K. "Casein kinase II inhibitors
isolated from two Brazilian plants Hymenaea parvifolia and Wulffia
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236. Matsunaga, K.; Nakatani,
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