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研究業績

1.  原著論文

Liu W, Xiong W, Liu W, Hirakawa J, Kawashima H. A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses.
Sci Rep (2023)13:15740. 
 
Abo H,Muraki A,Harusato A, Imura T, Suzuki M, Takahashi K, Denning TL, Kawashima H. N-acetylglucosamine-6-O-sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota.
JCI Insight  (2023) e165944.
 
Liu W, Xiong W, Liu W, Wei Z, Abo H, Kawashima H. Therapeutic Effects of an Anti-Sialyl Lewis x Antibody in a Murine Model of Acute Lung Injury.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy (2023) 42:97-103.
 
Arai T, Kokubo T, Tang R, Abo H, Terui A, Hirakawa J, Akita H, Kawashima H, Hisaka A, Hatakeyama H. Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor.
J Immunother Cancer (2022)10:e005657.
 
Umezawa F, Natsume M, Fukusada S, Nakajima K, Yamasaki F, Kawashima H, Kuo CW, Khoo KH, Shimura T, Yagi H, Kato K. Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of α-Dystroglycan.
Int J Mol Sci (2022) 23:6662.
 
Nakashima K, Sakai Y, Hoshino H, Umeda Y, Kawashima H, Sekido Y, Ishizuka T, Kobayashi M. Sulfated Glycans Recognized by S1 Monoclonal Antibody can Kawashima H. Identification of crucial amino acid residues for antimicrobial activity of angiogenin 4 and its modulation of gut microbiota in mice.
Front Microbiol (2022)13:900948.  
 
Kobayashi D, Hiono T, Ichii O, Nishihara S, Takase-Yoden S, Yamamoto K, Kawashima H, Isoda N, and Sakoda Y. Turkeys possess diverse Siaα2-3Gal glycans that facilitate their dual susceptibility to avian influenza viruses isolated from ducks and chickens.
Virus Res (2022) 315:198771.
 
Sawada J, Hiraoka N, Qi R, Jiang L, Fournier-Goss AE, Yoshida M, Kawashima H, and Komatsu M.
Transcriptome Analysis of Tumor Vasculature Identifies Molecular Signature of Tumor-Associated High Endothelial Venules that Predicts Breast Cancer Survival.
Cancer Immunol Res (2022) 10:468-481.
 
Yamasaki F, Umezawa F, Sensui T, Anzo M, Abo H, Kuo C-W, Khoo K-H, Kato K, Yagi H and Kawashima H.
Establishment of a novel monoclonal antibody against truncated glycoforms of -dystroglycan lacking matriglycans.
Biochem Biophys Res Commun (2021) 579:8-14.
 
Xiong W, Liu W, Nishida S, Komiyama D, Liu W, Hirakawa J and Kawashima H. 
Therapeutic effects of an anti-sialyl Lewis X antibody in a murine model of allergic asthma.
Int J Mol Sci (2021) 18:9961. 
 
Ichimiya T, Okamatsu M, Kinoshita T, Kobayashi D, Ichii O, Yamamoto N, Sakoda Y, Kida H, Kawashima H, Yamamoto K, Takase-Yoden S, Nishihara S.
Sulfated glycans containing NeuAcα2-3Gal facilitate the propagation of human H1N1 influenza A viruses in eggs.
Virology (2021) 562:29-39. 
 
Shoji T, Takaya A, Kusuya Y, Takahashi H, and Kawashima H.
Ribosome Profiling in Streptococcus pneumoniae reveals the role of methylation of 23S rRNA nucleotide G748 on ribosome stalling.
J Genet Genomic Sci (2021) 6:024
 
Brulois K, Rajaraman A, Szade A, Nordling S, Bogoslowski A, Dermadi D, Rahman M, Kiefel H, O'Hara E, Koning JJ, Kawashima H, Zhou B, Vestweber D, Red-Horse K, Mebius RE, Adams RH, Kubes P, Pan J, and Butcher EC.
 A molecular map of murine lymph node blood vascular endothelium at single cell resolution. 
Nat Commun (2020) 11:3798.
  
Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, and Nakayama J.
Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda.
J Histochem Cytochem (2019) 67:759-770.
 
Takaya A, Takeda H, Tashiro S, Kawashima H, and Yamamoto T.
Chaperone-mediated secretion switching from early to middle substrates in the type III secretion system encoded by Salmonella pathogenicity island 2.
J Biol Chem (2019) 294:3783-3793.
 
Kikuchi N, Ye J, Hirakawa J, Kawashima H.
Forced expression of CXCL10 prevents liver metastasis of colon carcinoma cells by the recruitment of natural killer cells.
Boil Pharm Bull (2019) 42:57-65.
この論文は、Biological Pharmaceutical Bulletin誌の表紙に掲載され、” Highlighted paper selected by Editor-in Chief ”に選定された。
 

Shulin L, Sakai Y., Hoshino H, Hirokawa M, Kawashima H, Higuchi K, Imamura Y and Kobayashi M.
High endothelial venule-like vessels and lymphocyte recruitment in diffuse sclerosing variant of papillary thyroid carcinoma.
Pathology (2016) 48:666-674.

Tsuboi K, Nishitani M, Takakura A, Imai Y, Komatsu M, and Kawashima H.
Autophagy protects against colitis by the maintenance of normal gut microflora and mucus secretion.
J Biol Chem (2015) 290:20511-20526.

Matsumura R, Hirakawa J, Sato K, Ikeda T, Nagai M, Fukuda M, Imai Y, and Kawashima H.
Novel antibodies reactive with sialyl Lewis X in both humans and mice define its critical role in leukocyte trafficking and contact hypersensitivity responses.
J Biol Chem (2015) 290:15313-15326.

 

Tsuboi K, Hirakawa J, Seki E, Imai Y, Yamaguchi Y, Fukuda M, and Kawashima H.
Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.
J Immunol (2013) 191:448-455.
この論文は、”Faculty of 1000 Prime”およびGlobal Medical Discoveryの”Key Scientific Article”に選定された。

Murai T, Sato C, Sato M, Nishiyama H, Suga M, Mio K, and Kawashima H.
Membrane cholesterol modulates the hyaluronan-binding ability of CD44 in T lymphocytes and controls rolling under shear flow.
J Cell Sci (2013) 126:3284-3294.

Ichikawa K, Asai T, Shimizu K, Yonezawa S, Urakami T, Miyauchi H, Kawashima H, Ishida T, Kiwada H, and Oku N.
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy.
J Control Release (2013) 167:284-289.

Ohya A, Kobayashi M, Sakai Y, Kawashima H, Kageyama S, and Nakayama J.
Lymphocyte recruitment via high endothelial venules in lymphoid stroma of Warthin's tumor.
Pathology (2013) 45:150-154, 2013.

Hirose M, Matsumura R, Sato K, Murai T, and Kawashima H.
Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH.
Biochem Biophys Res Commun (2011) 414:437-442.

Ohmichi Y, Hirakawa J, Imai Y, Fukuda M, and Kawashima H.
Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses.
J Exp Med (2011) 208:1015-1025.
この論文は、”Faculty of 1000 Biology”に選定された。

Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, Imai Y, Ito Y, Fukuda M, and Kawashima H.
Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing.
J Biol Chem (2010) 285:40864-40878.
この論文は、”JBC Papers of the Week” (JBC全掲載論文のトップ1%)に選定されるとともに、”Faculty of 1000 Biology”にも選定された。

Tobisawa Y, Imai Y, Fukuda M, and Kawashima H.
Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protective function in experimental colitis in mice.
J Biol Chem (2010) 285:6750-6760.

Bao X, Moseman EA, Saito H, Petryanik B, Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB, von Andrian UH and Fukuda M.
Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes.
Immunity (2010) 33:817-829.

Kawashima H, Hirakawa J, Tobisawa Y, Fukuda M, and Saga Y.
Conditional gene targeting in mouse high endothelial venules.
J Immunol (2009) 182:5461-5468.

Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SM, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, and Fukuda MN.
Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells.
Proc Natl Acad Sci USA (2009) 106:3095-3100.

Murai T, and Kawashima H.
A simple assay for hyaluronidase activity using fluorescence polarization.
Biochem Biophys Res Commun (2008) 376:620-624.

Mitoma J, Bao X, Petryanik B, Schaerli P, Gauguet JM, Yu SY, Kawashima H, Saito H, Ohtsubo K, Marth JD, Khoo KH, von Andrian UH, Lowe JB, and Fukuda M.
Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment.
Nature Immunology (2007) 8:409-418.

Hirose M, Murai T, and Kawashima H.
Elevation of rat plasma P-selectin in acute lung injury.
Biochim Biophys Acta-Mol Basis Dis (2007) 1772:382-389.

Hiraoka N, Petryniak B, Kawashima H, Mitoma J, Akama TO, Fukuda MN, Lowe JB, and Fukuda M.
Significant decrease in α1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing.
Glycobiology (2007) 17:277-293.

Kawashima H, Petryniak B, Hiraoka N, Mitoma J, Huckaby V, Nakayama J, Uchimura K, Kadomatsu K, Muramatsu T, Lowe JB and Fukuda M.
N-Acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.
Nature Immunology (2005) 6:1096-1104.
この論文は、Nature Immunology誌の表紙にフィーチャーされるとともに、News & Viewsにおいてその内容が紹介された。

Chen S, Kawashima H, Lowe JB, Lanier LL and Fukuda M.
Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.
J Exp Med (2005) 202:1679-1689.

Hiraoka N#, Kawashima H#, Petryniak B, Nakayama J, Mitoma J, Marth JD, Lowe JB, and Fukuda M.
Core 2 branching β1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing.
J Biol Chem (2004) 279:3058-3067. #equal contribution.

Murai T, Sougawa N, Kawashima H, Yamaguchi K, and Miyasaka M.
CD44-chondroitin sulfate interactions mediate leukocyte rolling under physiological flow conditions.
Immunol Lett (2004) 93:163-170.

Takeda M, Terasawa H, Sakakura M, Yamaguchi Y, Kajiwara M, Kawashima H, Miyasaka M, and Shimada I.
1H, 13C and 15N backbone resonance assignments of the hyaluronan-binding domain of CD44.
J Biomol NMR (2004) 29:97-98.

Ogawa D, Shikata K, Honke K, Sato S, Matsuda M, Nagase R, Tone A, Okada S, Usui H, Wada J, Miyasaka M, Kawashima H, Suzuki Y, Suzuki T, Taniguchi N, Hirahara Y, Tadano-Aritomi K, Ishizuka I, Tedder TF, and Makino H.
Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction.
J Biol Chem (2004) 279:2085-2090.

Kawashima H, Watanabe N, Hirose M, Sun X, Atarashi K, Kimura T, Shikata K, Matsuda M, Ogawa D, Heljasvaara R, Rehn M, Pihlajaniemi T, and Miyasaka M.
Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and
monocyte chemoattractant protein-1.
J Biol Chem (2003) 278:13069-13076.

Sugahara KN, Murai T, Nishinakamura H, Kawashima H, Saya H, and Miyasaka M.
Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells.
J Biol Chem (2003) 278:32259-32265.

Takeda M, Terasawa H, Sakakura M, Yamaguchi Y, Kajiwara M, Kawashima H, Miyasaka M, and Shimada I.
Hyaluronan recognition mode of CD44 revealed by cross-saturation and chemical shift perturbation experiments.
J Biol Chem (2003) 278:43550-43555.

Asano M, Nakae S, Kotani N, Shirafuji N, Nambu A, Hashimoto N, Kawashima H, Hirose M, Miyasaka M, Takasaki S, and Iwakura Y.
Impaired selectin-ligand biosynthesis and reduced inflammatory responses in β-1,4-galactosyltransferase-I-deficient mice.
Blood (2003) 102:1678-1685.

Morishima S, Morita I, Tokushima T, Kawashima H, Miyasaka M, Omura K, and Murota S.
Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation.
J Endocrinol (2003) 176:285-292.

Kawashima H, Atarashi K, Hirose M, Hirose J, Yamada S, Sugahara K, and Miyasaka M.
Oversulfated chondroitin/dermatan sulfates containing GlcAβ1/IdoAα1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines.
J Biol Chem (2002) 277:12921-12930.

Hirose J, Kawashima H, Swope-Willis M, Springer TA, Hasegawa H, Yoshie O, and Miyasaka M. 
Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC.
Biochim Biophys Acta-Gen Subjects (2002) 1571:219-224.

Ishihara Y, Kyono H, Serita F, Toya T, Kawashima H, and Miyasaka M.
Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride.
Inhal Toxicol (2002) 14:417-430.

Matsuda M, Shikata K, Shimizu F, Suzuki Y, Miyasaka M, Kawachi H, Kawashima H, Wada J, Sugimoto H, Shikata Y, Ogawa D, Tojo SJ, Akira K, and Makino H.
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis.
J Pathol (2002) 198:407-414.

Hirose J, Kawashima H, Yoshie O, Tashiro K, and Miyasaka M.
Versican interacts with chemokines and modulates cellular responses.
J Biol Chem (2001) 276:5228-5234.

Fujimoto T, Kawashima H, Tanaka T, Hirose M, Toyama-Sorimachi N, and Miyasaka M.
CD44 binds a chondroitin sulfate proteoglycan aggrecan.
Int Immunol (2001) 13:359-366.

Ishihara Y, Yasuhara T, Ishiyama S, Kawashima H, Miyasaka M, and Miyazaki T.
The role of leukocytes during acute phase inflammation in crystalline silica-induced lung injury.
Exp Lung Res (2001) 27:589-603.

Kawashima H, Hirose M, Hirose J, Nagakubo D, Plaas HKA, and Miyasaka M.
Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.
J Biol Chem (2000) 275:35448-35456.

Tajra L C, Martin X, Margonari J, Blanc-Brunat N, Ishibashi M, Vivier G, Steghens JP, Kawashima H, Miyasaka M, Dubernard J M, and Revillard JP.
Antibody-induced modulation of the leukocyte CD11b integrin prevents mild but not major renal ischaemic injury.
Nephrol Dial Transplant (2000) 15:1556-1561.

Azuma A, Takahashi S, Nose M, Araki K, Araki M, Takahashi T, Hirose M, Kawashima H, Miyasaka M, and Kudoh S.
Role of E-selectin in bleomycin induced lung fibrosis in mice.
Thorax (2000) 55:147-152.

Luo Z-J, Gotoh M, Grochowiecki T, Tanaka T, Kimura F, Kawashima H, Yagita H, Okumura K, and Miyasaka M.
Anergic T cells generated in vitro suppress rejection response to islet allografts.
Transplantation (2000) 69:2144-2148.

Ding Z, Kawashima H, and Miyasaka M.
Sulfatide binding and activation of leukocytes through a L-selectin-independent pathway.
J Leukoc Biol (2000) 68:65-72.

Kuno K, Okada Y, Kawashima H, Nakamura H, Miyasaka M, Ohno H, and Matsushima K.
ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.
FEBS Lett (2000) 478:241-245.

Watanabe N, Kawashima H, Li Y-F, and Miyasaka M.
Identification and characterization of ligands for L-selectin in the kidney. III. Characterization of
L-selectin reactive heparan sulfate proteoglycans.
J Biochem (1999) 125:826-831.

Li Y-F, Kawashima H, Watanabe N, and Miyasaka M.
Identification and characterization of ligands for L-selectin in the kidney. II. Expression of chondroitin sulfate and heparan sulfate proteoglycans reactive with L-selectin.
FEBS Lett (1999) 444:201-205.

Kawashima H, Li Y-F, Watanabe N, Hirose J, Hirose M, and Miyasaka M.
Identification and characterization of ligands for L-selectin in the kidney. I. Versican, a large chondroitin sulfate proteoglycan, is a ligand for L-selectin.
Int Immunol (1999) 11:393-405.

Shikata K, Suzuki Y, Wada J, Hirata K, Matsuda M, Kawashima H, Suzuki T, Iizuka M, Makino H, and Miyasaka M.
L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction.
J Pathol (1999) 188:93-99.

Kanoh N, Dai C-F, Tanaka T, Izawa D, Li Y-F, Kawashima H, and Miyasaka M.
Constitutive expression of GlyCAM-1 core protein in the rat cochlea.
Cell Adhesion and Commun (1999) 7:259-266.

Luo Z, Gotoh M, Grochowiecki T, Tanaka T, Kimura F, Kawashima H, Yagita H, Okumura K, and Miyasaka M.
Anergic cells generated in vitro suppress rejection response to islet allografts.
Transplantation Proc (1999) 31:623.

Tajra LC, Martin X, Margonari J, Blanc-Brunat N, Ishibashi M, Vivier G, Panaye G, Steghens JP, Kawashima H, Miyasaka M, Treille-Ritouet D, Dubernard JM, and Revillard JP.
In vivo effects of monoclonal antibodies against rat β2 integrins on kidney ischemia-reperfusion injury.
J Surg Res (1999) 87:32-38.

Hirose M, Kawashima H, and Miyasaka M.
A functional epitope on P-selectin that supports binding of P-selectin to P-selectin glycoprotein ligand-1 but not to sialyl Lewis X oligosaccharides.
Int Immunol (1998) 10:639-649.

Ohta Y, Gotoh M, Ohzato H, Fukuzaki T, Nishihara M, Dono K, Umeshita K, Sakon M, Yagita H, Okumura K, Tanaka T, Kawashima H, Miyasaka M, and Monden M.
Direct antigen presentation through binding of donor intercellular ahhesion molecule-1 to recipient lymphocyte function-associated antigen-1 molecules in xenograft rejection.
Transplantation (1998) 65:1094-1100.

Kawashima H, Watanabe N, Li Y-F, Hirose M, and Miyasaka M.
Characterization of a 180 kDa molecule apparently reactive with recombinant L-selectin.
Glycoconjugate J (1997) 14:321-330.

Ishiwatari-Hayasaka H, Kawashima H, Osawa T, Nagata S, and Miyasaka M.
Induction of cell death by chimeric L-selectin-Fas receptors.
Int Immunol (1997) 9:627-635.

Ding Z, Kawashima H, Suzuki Y, Suzuki T, Ward PA, and Miyasaka M.
A sulfatide receptor distinct from L-selectin is involved in lymphocyte activation.
FEBS Lett (1997) 418:310-314.

Ohta Y, Gotoh M, Ohzato H, Nishihara M, Dono K, Umeshita K, Sakon M, Monden M, Yagita H, Okumura K, Kawashima H, and Miyasaka M.
Both donor and recipient adhesion molecules play a critical role in inducing rejection of rat xenogenetic islets in mice.
Transplantation Proc (1997) 29:953.

Mulligan MS, Miyasaka M, Suzuki M, Kawashima H, Iizuka M, Hasegawa A, Kiso M, Warner RL, and Ward PA.
Anti-inflammatory effects of sulfatides in selectin-dependent acute lung injury.
Int Immunol (1995) 7:1107-1113.

Kawashima H, Yamamoto K, Osawa T, and Irimura T.
Purification and characterization of UDP-GlcNAc:Galb1-4Glc(NAc) b-1,3-N-acetylglucosaminyltransferase (poly-N-acetyllactosamine extension enzyme) from calf serum.
J Biol Chem (1993) 268:27118-27126.

Kawashima H, Murata T, Yamamoto K, Tateishi A, Irimura T, and Osawa T.
A simple method for the release of asparagine-linked oligosaccharides from a glycoprotein purified by SDS-polyacrylamide gel electrophoresis.
J Biochem (1992) 111:620-622.

Kawashima H, Sueyoshi S, Li H, Yamamoto K, and Osawa T.
Carbohydrate binding specificities of several poly-N-acetyllactosamine-binding lectins.
Glycoconjugate J (1990) 7:323-334.

Li H, Yamamoto K, Kawashima H, and Osawa T.
Structural requirements for the binding of oligosaccharides to immobilized lectin of Erythrina variegata (Linn) var. orientalis.
Glycoconjugate J (1990) 7:311-322.

Kawashima H, Tomaru A, Yamamoto K, Tsuji T, and Osawa T.
Monoclonal antibodies against human platelet membrane glycoprotein IIIa and collagen-induced platelet activation.
Chem Pharm Bull (Tokyo) (1989) 37:397-403.

 

２．著書

【欧文】
Kawashima H.
Glycosylation in high endothelial venules.
Taniguchi N, Endo T, Hart G and Wong C-H, ed.,
Glycoscience: Biology and Medicine, pp. 627-632 (2015)

Kawashima H.
Analysis of L-selectin-mediated cellular interactions under flow conditions.
Hirabayashi J, ed., Methods in Molecular Biology, Humana Press, Vol. 1200, pp. 401-412 (2014)

Kawashima H.
Generation of anti-sulfated glycan antibodies using sulfotransferase-deficient mice.
Inka B, ed., Methods in Molecular Biology, Humana Press, Vol. 1022, pp. 51-60 (2013)

Kawashima H.
Roles of GlcNAc-6-O-sulfotransferases in lymphoid and nonlymphoid tissues.
Fukuda M, ed., Methods in Enzymology, Academic Press, Vol. 479, pp. 243-256 (2010)

Kawashima H.
Determination of chemokine-glycosaminoglycan interaction specificity.
Fukuda M, ed., Methods in Enzymology, Academic Press, Vol. 416, pp. 254-263 (2006)

Kawashima H.
Functions of glycans revealed by gene inactivation of L-selectin ligand sulfotransferases in mice.
Fukuda M. ed., Methods in Enzymology, Academic Press, Vol. 416, pp. 279-290 (2006)

Miyasaka M, Tamatani T, and Kawashima H.
Biological significance of L-selectin (LECAM-1) and its ligand.
Masaki M, ed., Endothelium-Derived Factors and Vascular Functions, Elsevier Science B.V., pp. 249-252 (1994)

Miyasaka M, Ishimaru T, Suzuki Y, Tamatani T, and Kawashima H.
Expression of L-selectin (LECAM-1) ligands in the kidney.
Tsuchiya M et al., eds., Current Topics in Mucosal Immunology 1993, Elsevier Science B.V., pp. 367-371 (1994)

Irimura T and Kawashima H.
Detection and characterization of glycoprotein carbohydrate chains after electrophoretic
separation.
Dunbar BS, ed., Protein Blotting, IRL Press, pp. 155-161 (1994)
 
【和文】
川島博人
多細胞生物の特徴
入村達郎、辻勉編、「薬学生のための基礎シリーズ　基礎生命科学」、第7章分担、培風館、pp. 87-99 (2014)

廣瀬まゆみ、川島博人、宮坂昌之
セレクチンを介する接着の検出法
大島泰郎編、「基礎生化学実験法　第5巻　脂質・糖質・複合糖質」 、日本生化学会編、pp. 290-296 (2000)

渡辺哲史、川島博人
MAdCAM-1
竹市雅俊、宮坂昌之編、「細胞接着分子」、東京化学同人、 pp. 142-145 (1996)

廣瀬まゆみ、川島博人
PSGL-1
竹市雅俊、宮坂昌之編、「細胞接着分子」、東京化学同人、 pp. 146-149 (1996)

川島博人
L-セレクチン
竹市雅俊、宮坂昌之編、「細胞接着分子」、東京化学同人、 pp. 122-127 (1996)
 

３．総説

【欧文】
Sultana MF, Abo H and Kawashima H. Human and mouse angiogenins: Emerging insights and potential opportunities.
Microbiol (2022)13:1022945.
 
Murai T, Kawashima H, and Naor D. Editorial: Cell-cell and cell-matrix adhesion in immunobiology and cancer.
Front Immunol (2019) 10:3126. 
 
Kawashima H. and Fukuda M.
Sulfated glycans control lymphocyte homing.
Ann NY Acad Sci (2012) 1253:112-121.

Kawashima H.
Roles of the gel-forming MUC2 mucin and its O-glycosylation in the protection against colitis and
colorectal cancer.
Biol Pharm Bull (2012) 35:1637-1641.

Kawashima H.
Two roles of mucin sulfation.
Trends Glycosci Glycotechnol (2010) 22:211-225.

Kawashima H.
Roles of sulfated glycans in lymphocyte homing.
Biol Pharm Bull (2006) 29:2343-2349.

Kawashima H. and Miyasaka M.
Interaction of chondroitin sulfate proteoglycans with selectins, CD44, and chemokines.
Trends Glycosci Glycotechnol (2000) 12:283-294.

Kawashima H. Watanabe N, Hirose M, Li Y-F, Hirose J, and Miyasaka M.
Vascular and non-vascular ligands for L-selectin.
Cell Adhesion and Commun (1998) 6:135-139.

Miyasaka M, Kawashima H, Korenaga R, and Ando J.
Involvement of selectins in atherogenesis: a primary or secondary event?
Ann NY Acad Sci (1997) 811:25-35.

【和文】
平川城太朗、川島博人
新規抗糖鎖モノクローナル抗体を用いたリンパ球体内動態の解析
生化学(2018) 90:231-234.

 

川島博人
アレルギー鼻炎の発症とNALTの血管アドレシン
臨床免疫・アレルギー科　(2012) 57:693-700.

川島博人、福田穣
硫酸化糖鎖のリンパ球ホーミングにおける役割
医学のあゆみ　(2005) 213:979-983.

川島博人
獲得免疫における糖鎖の役割
生化学　(2004) 76:207-218.

新和之、平田多佳子、川島博人、寒川延子、Bo-Gie Yang、菅原一樹、宮坂昌之
コンドロイチン硫酸プロテオグリカンと白血球浸潤
実験医学 (2004) 22:123-130.

川島博人
コンドロイチン硫酸プロテオグリカンとセレクチン/CD44/ケモカインの相互作用
炎症・再生　(2002) 22:95-104.

新和之、川島博人、平田多佳子、宮坂昌之
L-セレクチンとCD44の共通リガンド、コンドロイチン硫酸プロテオグリカン
蛋白質 核酸 酵素　(2000) 47:2214-2220.

川島博人、廣瀬潤、宮坂昌之
プロテオグリカンによるケモカインの提示
臨床免疫　(2000) 33:166-172.

古賀友之、川島博人、宮坂昌之
バーシカン
臨床検査　(2000) 44:1147-1149.

古賀友之、川島博人、宮坂昌之
GlyCAM-1
臨床免疫　(2000) 34:398-401.

廣瀬潤、川島博人、宮坂昌之
プロテオグリカンとケモカインの相互作用
Molecular Medicine　(1999) 36:898-906.

藤本敬、川島博人、宮坂昌之
CD44とそのリガンドによる免疫応答の調節
Molecular Medicine　(1999) 36:914-920.

村井稔幸、川島博人、田中稔之、宮坂昌之
リンパ球ホーミングの分子機構
実験医学　(1999) 17:1459-1464.

川島博人、李永菲、宮坂昌之
腎におけるL-セレクチンリガンドの発現とその白血球浸潤への関与
炎症　(1998) 18:419-424.

中出真司、川島博人、宮坂昌之
セレクチンファミリー
臨床免疫　(1998) 30:16-24.

川島博人、宮坂昌之
ホーミングレセプターL-セレクチンの新しいリガンド
Molecular Medicine 臨時増刊号「免疫1998-1999」 (1998) 196-205 .

川島博人
リンパ球のホーミングと接着分子
Annual Review 免疫 (1995) 139-147.

川島博人
L-セレクチンに対するリガンド
現代医療 (1994) 26:3073-3078.