Japanese Ver.

Reserch Projects

Development of Efficient Methods for Synthesizing Bioactive Molecules

The research interests of the Nemoto group lie in the field of organic synthesis. We are investigating the development of highly efficient and selective catalytic synthetic methods applicable to the synthesis of highly functionalized bioactive molecules. The followings are the representative synthetic methods recently developed our group.

(1) Dearomatization of phenols using Friedel-Crafts-type transition-metal catalysis

240

(2) Development of novel synthetic methods based on the chemistry of metal carbenoids

240

(3) Efficient synthesis of small-sized ring-containing molecules

240

top of the page

Development of Efficient Synthetic Methods based on Cascade and Relay Catalysis

The use of cascade or relay catalysis is highly effective for increasing the synthetic efficiency. Towards this end, we are focusing on the development of novel sequential synthetic processes using a single catalyst with multi-functional properties, as well as using a multi-catalytic system. The followings are the representative processes of this class developed by our laboratory.

(1) Pd- or Pt-catalyzed cascade processes for the synthesis of 3,4-fused tricyclic indole derivatives

240

(2) Synthesis of fused-cyclic molecules using Brønsted acid-promoted cascade processes

240

(3) Relay catalysis (One-pot sequential multi-catalytic process)

240

top of the page

Synthetic Study on Bioactive Organic Molecules and Natural Products

We are investigating the synthesis of bioactive organic molecules and natural products based on our own catalytic synthetic methods. Current synthetic targets are shown below.

389

Synthesis of Functional Organic Molecules for the Control of Epigenetic Alterations in Human Cancers

This is a cooperative research with Prof. Atsushi Kaneda in Graduate School of Medicine, Chiba University.

Website in Japanese

top of the page

やっかちゃん ナスちゃん